LongevityMap variant
Entry Details
- Longevity Association
- Non-significant
- Population
- Jordanian
- Study Design
- SNPs rs266729 (-11377G/C), rs2241766 (+45T/G), and rs1501299 (+276 G/T) of adiponectin gene (ADIPQO) and rs7799039 (-2548C/A) SNP of leptin (LEP) gene were genotyped in 110 randomly selected elderly subjects (>85 years old) with mean age of 90.2 years, and 120 young control subjects (range from 20 to 50 years) with mean age of 32.0 years
- Conclusions
- No significant differences were detected in the genotype and allele frequencies of examined gene variants between the two groups (p > 0.05). However, when gender was considered, genotypes and alleles frequencies of rs1501299 SNP in ADIPOQ gene and rs7799039 in LEP gene were significantly associated with longevity in men (p < 0.02) but not in women (p > 0.05).
- Identifier
- rs266729
- In Other Studies (IDs)
- 583
- Cytogenetic Location
- 3q27.3
- UCSC Genome Browser
- View 3q27.3 on the UCSC genome browser
Gene details
- HGNC symbol
- ADIPOQ
- Aliases
- ACDC; ADPN; APM1; APM-1; GBP28; ACRP30; ADIPQTL1
- Common name
- adiponectin, C1Q and collagen domain containing
- Description
- This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and hormonal processes. Mutations in this gene are associated with adiponectin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Apr 2010]
- Other longevity studies of this gene
- 8
- OMIM
- 605441
- Ensembl
- ENSG00000181092
- UniProt/Swiss-Prot
- A8K660_HUMAN
- Entrez Gene
- 9370
- UniGene
- 80485
- HapMap
- View on HapMap