LongevityMap variant
- Longevity Association
- Significant
- Population
- Danish
- Study Design
- 38 genes (311 SNPs) belonging to pro-antioxidant pathways were investigated for the association with physical and cognitive performances in a Cohort of 1089 Danish nonagenarians. For each gene analyzed in the pro-antioxidant pathway, the influence on longitudinal survival was tested.
- Conclusions
- NDUFS1, TXNRD1, SOD2 and UCP3 were found significantly associated with lifespan in the female cohort. This result is consistent with their associations with physical functioning and suggests that the variability of genes in the pro-antioxidant pathway can influence survival through an effect on physical performances, at least in the analyzed cohort.
- HGNC symbol
- SOD2
- Aliases
- IPOB; IPO-B; MNSOD; MVCD6; Mn-SOD
- Common name
- superoxide dismutase 2
- Description
- This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. [provided by RefSeq, Apr 2016]
- Other longevity studies of this gene
- 21
- OMIM
- 147460
- Ensembl
- ENSG00000112096
- UniProt/Swiss-Prot
- A0A0C4DFU1_HUMAN
- Entrez Gene
- 6648
- UniGene
- 487046
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- sod-2
- Caenorhabditis elegans
- sod-3
- Danio rerio
- sod2
- Drosophila melanogaster
- Sod2
- Mus musculus
- Sod2
- Rattus norvegicus
- Sod2
- Saccharomyces cerevisiae
- SOD2
- Schizosaccharomyces pombe
- SPBC16A3.14
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as SOD2
- A homolog of this gene for Drosophila melanogaster is present as Sod2
- A homolog of this gene for Mus musculus is present as Sod2
- A homolog of this gene for Caenorhabditis elegans is present as sod-2
- GenAge human genes
- This gene is present as SOD2
- GenDR gene manipulations
- A homolog of this gene for Saccharomyces cerevisiae is present as SOD2
- CellAge
- This gene is present as SOD2
Dato et al. (2014)
Other variants which are also part of this study
