Caenorhabditis elegans GenDR Dietary Restriction Gene Manipulation: ubc-18

Gene Information (Entrez Gene ID: 175985)

Symbol
ubc-18
Name
UBiquitin Conjugating enzyme 18
Organism
Caenorhabditis elegans (AnAge)
Entrez Gene ID
175985

Potential relevance to dietary restriction and ageing

Observations

ubc-18 overexpression is unable to extend lifespan. Loss of ubc-18 function by mutation or RNAi reduces lifespan at 25 degree Celsius, but only slightly at 20 degree Celsius. RNAi depletion of ubc-18 completely suppresses increased longevity of eat-2 mutants [2572].

References

    Homologs

    Danio rerio
    ube2l3a
    Danio rerio
    ube2l3b
    Drosophila melanogaster
    Ubc84D
    Drosophila melanogaster
    CG17030
    Drosophila melanogaster
    Ubc10
    Homo sapiens
    UBE2L3
    Homo sapiens
    UBE2L5P
    Mus musculus
    Ube2l3
    Mus musculus
    Ube2l3
    Saccharomyces cerevisiae
    UBC5

    External links

    WormBase
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    Entrez Gene
    ID 175985
    Homologues
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    UniProt
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    Internet
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