Caenorhabditis elegans GenDR Dietary Restriction Gene Manipulation: gas-1

Gene Information (Entrez Gene ID: 181646)

Symbol
gas-1
Name
Probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
Organism
Caenorhabditis elegans (AnAge)
Entrez Gene ID
181646

Potential relevance to dietary restriction and ageing

Observations

Under normal conditions downregulation of gas-1 in worms increased mean lifespan by 16%. When worms lacking gas-1 were subjected to dietary restriction the difference in lifespan extension was reduced compared to the control (30% compared to 51% for the control). Thus downregulation of gas-1 triggers a dietary restriction like effect.

References

    In other databases

    GenAge model organism genes
    • This gene is present as gas-1

    Homologs

    Danio rerio
    ndufs2
    Drosophila melanogaster
    CG1970
    Drosophila melanogaster
    CG11913
    Homo sapiens
    NDUFS2
    Mus musculus
    Ndufs2
    Rattus norvegicus
    Ndufs2

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    ID 181646
    Homologues
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    UniProt
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    Internet
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