Drosophila melanogaster GenDR Dietary Restriction Gene Manipulation: Gdh

Gene Information (Entrez Gene ID: 42832)

Symbol
Gdh
Aliases
CG5320 DHE3 Dmel\CG5320 gdh GDH GLU-D Glud GLUD GLUD pre-mRNA
Name
Glutamate dehydrogenase
Organism
Drosophila melanogaster (AnAge)
Entrez Gene ID
42832

Potential relevance to dietary restriction and ageing

Observations

Wild type flies and flies containing mutant Gdh (71% activity compared to the wild type) were subjected to dietary restriction. Both wild type and mutant flies showed a significant increase in lifespan under dietary restriction compared to normal conditions. However, flies with mutant Gdh had a significantly longer lifespan (more than 14 days) than the wild type, demonstrating that decreased Gdh activity enhances the effects of dietary restriction.

References

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Saccharomyces cerevisiae is present as GDH3
    • A homolog of this gene for Caenorhabditis elegans is present as gdh-1

    Homologs

    Caenorhabditis elegans
    gdh-1
    Danio rerio
    glud1a
    Danio rerio
    glud1b
    Homo sapiens
    GLUD1
    Homo sapiens
    GLUD2
    Mus musculus
    Glud1
    Rattus norvegicus
    Glud1
    Saccharomyces cerevisiae
    GDH3
    Saccharomyces cerevisiae
    GDH1
    Schizosaccharomyces pombe
    gdh1

    External links

    FlyBase
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    Ensembl
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    Entrez Gene
    ID 42832
    Homologues
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    UniProt
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    Internet
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