GenDR Dietary Restriction Gene Manipulation: sug
Gene Information (Entrez Gene ID: 36424)
- Symbol
- sug
- Aliases
- CG3850 Dmel\CG3850
- Name
- sugarbabe
- Organism
- Drosophila melanogaster (AnAge)
- Entrez Gene ID
- 36424
Potential relevance to dietary restriction and ageing
- Observations
-
Depletion of sug using RNA interference reduced lifespan in flies and reduced the lifespan extending effects of dietary restriction by 37%. Sug was found to act downstream of Ire1, facilitating the metabolic shift towards lipid usage under dietary restriction. Sug expression rescued the short lifespan of Ire1 depleted flies on DR.
- References
-
In other databases
- GenAge model organism genes
- This gene is present as sug
Homologs
- Caenorhabditis elegans
- ztf-14
- Caenorhabditis elegans
- tra-1
- Danio rerio
- glis2b
- Danio rerio
- glis2a
- Homo sapiens
- GLIS2
- Mus musculus
- Glis2
- Rattus norvegicus
- Glis2
External links
- FlyBase
- Search
- Ensembl
- Search
- Entrez Gene
- ID 36424
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar