GenDR Dietary Restriction Gene Manipulation: mlk-1
Gene Information (Entrez Gene ID: 178895)
- human MLK (Mixed Lineage Kinase) homolog
- Caenorhabditis elegans (AnAge)
- Entrez Gene ID
Potential relevance to dietary restriction and ageing
Loss-of-function mlk-1 mutant reduces the lifespan extension of intermitent fasting. In the wild-type N2 worms, intermitent fasting increases lifespan by ~77%, while in the mlk-1 mutants lifespan extension is reduced to ~50%.
- Schizosaccharomyces pombe