Caenorhabditis elegans GenDR Dietary Restriction Gene Manipulation: mek-1

Gene Information (Entrez Gene ID: 181004)

Symbol
mek-1
Name
MAP kinase kinase or Erk Kinase
Organism
Caenorhabditis elegans (AnAge)
Entrez Gene ID
181004

Potential relevance to dietary restriction and ageing

Observations

Loss-of-function mek-1 mutant reduces the lifespan extension of intermitent fasting. In the wild-type N2 worms, intermitent fasting increases lifespan by ~77%, while in the mek-1 mutants lifespan extension is reduced to ~22%.

References

    In other databases

    CellAge
    • A homolog of this gene for Homo sapiens is present as MAP2K7

    Homologs

    Danio rerio
    map2k7
    Drosophila melanogaster
    hep
    Homo sapiens
    MAP2K7
    Mus musculus
    Map2k7
    Mus musculus
    Map2k7
    Rattus norvegicus
    Map2k7
    Saccharomyces cerevisiae
    PBS2

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    ID 181004
    Homologues
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    UniProt
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    Internet
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