Caenorhabditis elegans GenDR Dietary Restriction Gene Manipulation: kgb-1

Gene Information (Entrez Gene ID: 176866)

Symbol
kgb-1
Name
Kinase, GLH-Binding
Organism
Caenorhabditis elegans (AnAge)
Entrez Gene ID
176866

Potential relevance to dietary restriction and ageing

Observations

Loss-of-function kgb-1 mutant or inhibition of kgb-1 by post-developmental RNA interference reduces the lifespan extension of intermitent fasting. In the wild-type N2 worms, intermitent fasting increases lifespan by ~77%, while in the kgb-1 mutants lifespan extension is reduced to 23-24%.

References

    Homologs

    Saccharomyces cerevisiae
    HOG1

    External links

    WormBase
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    Entrez Gene
    ID 176866
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