Caenorhabditis elegans GenDR Dietary Restriction Gene Manipulation: cha-1

Gene Information (Entrez Gene ID: 13192683)

Symbol
cha-1
Name
abnormal CHoline Acetyltransferase 1
Organism
Caenorhabditis elegans (AnAge)
Entrez Gene ID
13192683

Potential relevance to dietary restriction and ageing

Observations

Mutation or RNA interference of cha-1 extends lifespan on killed or live bacteria as well as in liquid culture medium [2603]. cha-1(TY1652) mutation extends mean, 75%ile, and maximum lifespan by 23, 29, and 38%. The cha-1(PR1152) allele extends mean, 75%ile, and maximum lifespan by 22-49, 18-25, and 11-21%. Lifespan extension by cha-1 mutation is not abolished by daf-16 RNAi inactivation. eat-2 RNAi shortens the lifespan of cha-1 mutants [2603]. cha-1 participates in determining pharyngeal pumping rate to affect food intake [2620].

References

    Homologs

    No homologs found

    External links

    WormBase
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    Entrez Gene
    ID 13192683
    Homologues
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