Caenorhabditis elegans GenDR Dietary Restriction Gene Manipulation: trx-1

Gene Information (Entrez Gene ID: 181863)

Symbol
trx-1
Name
ThioRedoXin 1
Organism
Caenorhabditis elegans (AnAge)
Entrez Gene ID
181863

Potential relevance to dietary restriction and ageing

Observations

Thioredoxins regulate many cellular redox processes. trx-1 is mainly associated with neurons and is expressed in ASJ ciliated sensory neurons and to some extent also on the posterior-most internal cells. trx-1 null mutant display reduced mean and maximum lifespan [2613]. trx-1 overexpression extends lifespan in wild-type but not in eat-2 mutants. trx-1 deletion completely suppresses the lifespan extension caused by eat-2 mutation, but only partially suppresses that by daf-2 mutations. Ectopic expression of trx-1 in ASJ neurons (but not in the intestine) in trx-1 mutants rescues the lifespan-extension conferred by eat-2 mutation. trx-1 deletion almost completely suppresses lifespan extension induced by dietary deprivation (DD). DD upregulates trx-1 expression in ASJ neurons. DR activates trx-1 in ASJ neurons which in turn triggers a trx-1-dependent non-cell autonomous mechanism to extend adult lifespan [2612].

References

    In other databases

    GenAge model organism genes
    • This gene is present as trx-1
    • A homolog of this gene for Drosophila melanogaster is present as Trx-2
    • A homolog of this gene for Drosophila melanogaster is present as TrxT
    • A homolog of this gene for Saccharomyces cerevisiae is present as TRX1

    Homologs

    Drosophila melanogaster
    TrxT
    Drosophila melanogaster
    Trx-2
    Drosophila melanogaster
    CG13473
    Drosophila melanogaster
    dhd
    Saccharomyces cerevisiae
    TRX1
    Saccharomyces cerevisiae
    TRX2
    Schizosaccharomyces pombe
    trx1

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    ID 181863
    Homologues
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    UniProt
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    Internet
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