Cell Senescence Entries for ASXL2

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Mutation, Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Daou et al. (2016) The BAP1/ASXL2 Histone H2A Deubiquitinase Complex Regulates Cell Proliferation and Is Disrupted in Cancer. J Biol Chem 290(48)28643-63 (PubMed)

ASXL2 Gene Information

HGNC symbol
ASXL2 
Aliases
ASXH2; FLJ10898; KIAA1685 
Common name
ASXL transcriptional regulator 2 
Entrez Id
55252
Description
This gene encodes a member of a family of epigenetic regulators that bind various histone-modifying enzymes and are involved in the assembly of transcription factors at specific genomic loci. Naturally occurring mutations in this gene are associated with cancer in several tissue types (breast, bladder, pancreas, ovary, prostate, and blood). This gene plays an important role in neurodevelopment, cardiac function, adipogenesis, and osteoclastogenesis. [provided by RefSeq, Feb 2017].

ASXL2 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:45944; positive regulation of transcription by RNA polymerase II
GO:9887; animal organ morphogenesis
GO:45600; positive regulation of fat cell differentiation
GO:35360; positive regulation of peroxisome proliferator activated receptor signaling pathway
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:35517; PR-DUB complex
Function: GO:46872; metal ion binding
GO:3677; DNA binding
GO:3682; chromatin binding
GO:42975; peroxisome proliferator activated receptor binding
GO:5515; protein binding
Show all GO terms

Homologs of ASXL2 in Model Organisms

Danio rerio
asxl2
Drosophila melanogaster
Asx
Mus musculus
Asxl2
Rattus norvegicus
Asxl2

External links

OMIM
612991
Ensembl
ENSG00000143970
Entrez Gene
55252
UniGene
229304
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ASXL2
GeneCards
ASXL2