Cell Senescence Entries for ACER2
- Cell Types
- Lung cancer
- Cell Lines
- H1299
- Cancer Cell?
- Yes
- Method
- Knockout, Overexpression
- Type of senescence
- Replicative, Stress-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Xu et al. (2019) Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2. Cell Death Differ 25(5)841-856 (PubMed)
ACER2 Gene Information
- HGNC symbol
- ACER2
- Aliases
- ALKCDase2; ASAH3L; FLJ41587
- Common name
- alkaline ceramidase 2
- Entrez Id
- 340485
- Description
- The sphingolipid metabolite sphingosine-1-phosphate promotes cell proliferation and survival, whereas its precursor, sphingosine, has the opposite effect. The ceramidase ACER2 hydrolyzes very long chain ceramides to generate sphingosine (Xu et al., 2006 [PubMed 16940153]).[supplied by OMIM, Jul 2010].
ACER2 Ontologies
- Gene Ontology
-
Process: GO:6629; lipid metabolic process
GO:6665; sphingolipid metabolic process
GO:6974; cellular response to DNA damage stimulus
GO:6672; ceramide metabolic process
GO:8284; positive regulation of cell population proliferation
GO:42981; regulation of apoptotic process
GO:46512; sphingosine biosynthetic process
GO:10506; regulation of autophagy
GO:30148; sphingolipid biosynthetic process
GO:1953; negative regulation of cell-matrix adhesion
GO:30330; DNA damage response, signal transduction by p53 class mediator
And 8 more GO terms Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5794; Golgi apparatus
GO:139; Golgi membrane
GO:30173; integral component of Golgi membrane
Function: GO:46872; metal ion binding
GO:16787; hydrolase activity
GO:16811; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
GO:17040; N-acylsphingosine amidohydrolase activity
GO:102121; ceramidase activity
GO:71633; dihydroceramidase activity
Homologs of ACER2 in Model Organisms
- Caenorhabditis elegans
- W02F12.2
- Danio rerio
- ACER2
- Drosophila melanogaster
- bwa
- Mus musculus
- Acer2
- Rattus norvegicus
- Acer2
In other databases
- GenAge microarray genes
- This gene is present as ACER2
External links
- OMIM
- 613492
- Ensembl
- ENSG00000177076
- Entrez Gene
- 340485
- UniGene
- 99785
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- ACER2
- GeneCards
- ACER2