Cell Senescence Entries for AGR2
- Cell Types
- Prostate cancer
- Cell Lines
- DU145, LNCaP, PC-3
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Hu et al. (2012) Knockdown of AGR2 induces cellular senescence in prostate cancer cells. Carcinogenesis 33(6)1178-86 (PubMed)
AGR2 Gene Information
- HGNC symbol
- AGR2
- Aliases
- AG2; HAG-2; PDIA17; XAG-2
- Common name
- anterior gradient 2, protein disulphide isomerase family member
- Entrez Id
- 10551
- Description
- This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This protein plays a role in cell migration, cellular transformation and metastasis and is as a p53 inhibitor. As an ER-localized molecular chaperone, it plays a role in the folding, trafficking, and assembly of cysteine-rich transmembrane receptors and the cysteine-rich intestinal gylcoprotein mucin. This gene has been implicated in inflammatory bowel disease and cancer progression. [provided by RefSeq, Mar 2017].
AGR2 Ontologies
- Gene Ontology
-
Process: GO:48546; digestive tract morphogenesis
GO:10628; positive regulation of gene expression
GO:60548; negative regulation of cell death
GO:1903078; positive regulation of protein localization to plasma membrane
GO:45742; positive regulation of epidermal growth factor receptor signaling pathway
GO:10811; positive regulation of cell-substrate adhesion
GO:48639; positive regulation of developmental growth
GO:60480; lung goblet cell differentiation
GO:70254; mucus secretion
GO:1903896; positive regulation of IRE1-mediated unfolded protein response
GO:1903899; positive regulation of PERK-mediated unfolded protein response
And 1 more GO terms Cellular component: GO:5783; endoplasmic reticulum
GO:5576; extracellular region
GO:5615; extracellular space
Function: GO:42802; identical protein binding
GO:5515; protein binding
GO:2162; dystroglycan binding
GO:5154; epidermal growth factor receptor binding
Homologs of AGR2 in Model Organisms
- Caenorhabditis elegans
- Y57A10A.23
- Caenorhabditis elegans
- F49H12.5
- Danio rerio
- agr2
- Mus musculus
- Agr2
- Rattus norvegicus
- Agr2
External links
- OMIM
- 606358
- Ensembl
- ENSG00000106541
- Entrez Gene
- 10551
- UniGene
- 530009
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- AGR2
- GeneCards
- AGR2