Cell Senescence Entries for ZMYND11
- Cell Types
- Lung fibroblast
- Cell Lines
- IMR-90, WI-38
- Cancer Cell?
- No
- Method
- Knockdown
- Type of senescence
- Unclear
- Senescence Effect
- Inhibits
- Primary Reference
- Zhang et al. (2008) BS69 is involved in cellular senescence through the p53-p21Cip1 pathway. EMBO Rep 8(10)952-8 (PubMed)
ZMYND11 Gene Information
- HGNC symbol
- ZMYND11
- Aliases
- BS69
- Common name
- zinc finger MYND-type containing 11
- Entrez Id
- 10771
- Description
- The protein encoded by this gene was first identified by its ability to bind the adenovirus E1A protein. The protein localizes to the nucleus. It functions as a transcriptional repressor, and expression of E1A inhibits this repression. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
ZMYND11 Ontologies
- Gene Ontology
-
Process: GO:7049; cell cycle
GO:6325; chromatin organization
GO:51607; defense response to virus
GO:45892; negative regulation of transcription, DNA-templated
GO:46329; negative regulation of JNK cascade
GO:43124; negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:2001237; negative regulation of extrinsic apoptotic signaling pathway
GO:34243; regulation of transcription elongation from RNA polymerase II promoter
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:5694; chromosome
GO:16020; membrane
GO:16021; integral component of membrane
Function: GO:46872; metal ion binding
GO:3677; DNA binding
GO:8270; zinc ion binding
GO:5515; protein binding
GO:35064; methylated histone binding
GO:3690; double-stranded DNA binding
GO:3714; transcription corepressor activity
Homologs of ZMYND11 in Model Organisms
- Caenorhabditis elegans
- bra-1
- Caenorhabditis elegans
- bra-2
- Danio rerio
- zmynd11
- Drosophila melanogaster
- CG8569
- Mus musculus
- Zmynd11
- Rattus norvegicus
- Zmynd11
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as bra-1
External links
- OMIM
- 608668
- Ensembl
- ENSG00000015171
- Entrez Gene
- 10771
- UniGene
- 740145
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- ZMYND11
- GeneCards
- ZMYND11