Cell Senescence Entries for ZMYND11

Cell Types
Lung fibroblast
Cell Lines
IMR-90, WI-38
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Zhang et al. (2008) BS69 is involved in cellular senescence through the p53-p21Cip1 pathway. EMBO Rep 8(10)952-8 (PubMed)

ZMYND11 Gene Information

HGNC symbol
ZMYND11 
Aliases
BS69 
Common name
zinc finger MYND-type containing 11 
Entrez Id
10771
Description
The protein encoded by this gene was first identified by its ability to bind the adenovirus E1A protein. The protein localizes to the nucleus. It functions as a transcriptional repressor, and expression of E1A inhibits this repression. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].

ZMYND11 Ontologies

Gene Ontology
Process: GO:7049; cell cycle
GO:6325; chromatin organization
GO:51607; defense response to virus
GO:45892; negative regulation of transcription, DNA-templated
GO:46329; negative regulation of JNK cascade
GO:43124; negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:2001237; negative regulation of extrinsic apoptotic signaling pathway
GO:34243; regulation of transcription elongation from RNA polymerase II promoter
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:5694; chromosome
GO:16020; membrane
GO:16021; integral component of membrane
Function: GO:46872; metal ion binding
GO:3677; DNA binding
GO:8270; zinc ion binding
GO:5515; protein binding
GO:35064; methylated histone binding
GO:3690; double-stranded DNA binding
GO:3714; transcription corepressor activity
Show all GO terms

Homologs of ZMYND11 in Model Organisms

Caenorhabditis elegans
bra-1
Caenorhabditis elegans
bra-2
Danio rerio
zmynd11
Drosophila melanogaster
CG8569
Mus musculus
Zmynd11
Rattus norvegicus
Zmynd11

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as bra-1

External links

OMIM
608668
Ensembl
ENSG00000015171
Entrez Gene
10771
UniGene
740145
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ZMYND11
GeneCards
ZMYND11