Cell Senescence Entries for ZFP36

Cell Types
Cervical cancer
Cell Lines
HeLa
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Sanduja et al. (2010) The mRNA decay factor tristetraprolin (TTP) induces senescence in human papillomavirus-transformed cervical cancer cells by targeting E6-AP ubiquitin ligase. Aging (Albany NY) 1(9)803-17 (PubMed)

ZFP36 Gene Information

HGNC symbol
ZFP36 
Aliases
G0S24; NUP475; RNF162A; TIS11; TTP 
Common name
ZFP36 ring finger protein 
Entrez Id
7538
Description

ZFP36 Ontologies

Gene Ontology
Process: GO:51028; mRNA transport
GO:122; negative regulation of transcription by RNA polymerase II
GO:31047; gene silencing by RNA
GO:43488; regulation of mRNA stability
GO:165; MAPK cascade
GO:288; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:6402; mRNA catabolic process
GO:71222; cellular response to lipopolysaccharide
GO:61158; 3'-UTR-mediated mRNA destabilization
GO:60213; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:1900153; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
And 31 more GO terms
Cellular component: GO:5737; cytoplasm
GO:5634; nucleus
GO:1990904; ribonucleoprotein complex
GO:932; P-body
GO:10494; cytoplasmic stress granule
GO:5829; cytosol
GO:30014; CCR4-NOT complex
GO:70578; RISC-loading complex
Function: GO:5515; protein binding
GO:3723; RNA binding
GO:3729; mRNA binding
GO:46872; metal ion binding
GO:3677; DNA binding
GO:35925; mRNA 3'-UTR AU-rich region binding
GO:19901; protein kinase binding
GO:19899; enzyme binding
GO:71889; 14-3-3 protein binding
GO:44877; protein-containing complex binding
GO:70063; RNA polymerase binding
And 3 more GO terms
Show all GO terms

Homologs of ZFP36 in Model Organisms

Caenorhabditis elegans
oma-2
Caenorhabditis elegans
ccch-1
Caenorhabditis elegans
oma-1
Caenorhabditis elegans
moe-3
Danio rerio
zgc:162730
Drosophila melanogaster
Tis11
Mus musculus
Zfp36
Rattus norvegicus
Zfp36
Saccharomyces cerevisiae
CTH1
Saccharomyces cerevisiae
TIS11

In other databases

GenAge model organism genes
  • A homolog of this gene for Saccharomyces cerevisiae is present as CTH1
  • A homolog of this gene for Saccharomyces cerevisiae is present as TIS11
GenAge microarray genes
  • This gene is present as ZFP36

External links

OMIM
190700
Ensembl
ENSG00000128016
Entrez Gene
7538
UniGene
534052
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ZFP36
GeneCards
ZFP36