Cell Senescence Entries for YPEL3

Cell Types
Breast cancer
Cell Lines
MCF-7
Cancer Cell?
Yes
Method
Knockdown, Overexpression
Type of senescence
Stress-induced
Senescence Effect
Induces
Observations
YPEL3 expression, which is induced by the removal of estrogen or treatment with tamoxifen, triggered cellular senescence in breast cancer cells (MCF-7), whilst loss of YPEL3 increased the growth rate of MCF-7 cells.
Primary Reference

    YPEL3 Gene Information

    HGNC symbol
    YPEL3 
    Aliases
     
    Common name
    yippee like 3 
    Entrez Id
    83719
    Description

    YPEL3 Ontologies

    Gene Ontology
    Process: GO:2000774; positive regulation of cellular senescence
    Cellular component: GO:5730; nucleolus
    Function: GO:46872; metal ion binding
    Show all GO terms

    Homologs of YPEL3 in Model Organisms

    Caenorhabditis elegans
    F37A8.5
    Danio rerio
    ypel3
    Drosophila melanogaster
    CG15309
    Mus musculus
    Ypel3
    Rattus norvegicus
    Ypel3
    Saccharomyces cerevisiae
    MOH1

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Saccharomyces cerevisiae is present as MOH1

    External links

    OMIM
    609724
    Ensembl
    ENSG00000090238
    Entrez Gene
    83719
    UniGene
    513491
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    YPEL3
    GeneCards
    YPEL3