Cell Senescence Entries for WRN

Cell Types
Fibroblast, WRN syndrome fibroblast
Cell Lines
AG00780, AG03141
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Observations
WRN expression was required to avoid cellular senescence upon MYC up-regulation in hTERT-immortalized fibroblasts. Cells that were WRN depleted lost proliferative capacity and showed increased SA-beta-galactosidase activity. Thus, WRN suppresses Myc-induced senescence.
Primary Reference

    WRN Gene Information

    HGNC symbol
    WRN 
    Aliases
    RECQ3; RECQL2; RECQL3 
    Common name
    Werner syndrome RecQ like helicase 
    Entrez Id
    7486
    Description
    This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging. [provided by RefSeq, Jul 2008]

    WRN Ontologies

    Gene Ontology
    Process: GO:32508; DNA duplex unwinding
    GO:6259; DNA metabolic process
    GO:6260; DNA replication
    GO:731; DNA synthesis involved in DNA repair
    GO:44806; G-quadruplex DNA unwinding
    GO:7568; aging
    GO:6284; base-excision repair
    GO:7420; brain development
    GO:7569; cell aging
    GO:6974; cellular response to DNA damage stimulus
    GO:71480; cellular response to gamma radiation
    And 20 more GO terms
    Cellular component: GO:32389; MutLalpha complex
    GO:5813; centrosome
    GO:5694; chromosome
    GO:781; chromosome, telomeric region
    GO:5737; cytoplasm
    GO:43005; neuron projection
    GO:16607; nuclear speck
    GO:5730; nucleolus
    GO:5654; nucleoplasm
    GO:5657; replication fork
    Function: GO:43138; 3'-5' DNA helicase activity
    GO:8408; 3'-5' exonuclease activity
    GO:70337; 3'-flap-structured DNA binding
    GO:5524; ATP binding
    GO:43140; ATP-dependent 3'-5' DNA helicase activity
    GO:4003; ATP-dependent DNA helicase activity
    GO:16887; ATPase activity
    GO:3677; DNA binding
    GO:3678; DNA helicase activity
    GO:51880; G-quadruplex DNA binding
    GO:403; Y-form DNA binding
    And 16 more GO terms
    Show all GO terms

    Homologs of WRN in Model Organisms

    Caenorhabditis elegans
    wrn-1
    Danio rerio
    wrn
    Mus musculus
    Wrn
    Rattus norvegicus
    Wrn
    Saccharomyces cerevisiae
    SGS1

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Saccharomyces cerevisiae is present as SGS1
    GenAge human genes
    • This gene is present as WRN
    LongevityMap
    • This gene is present as WRN

    External links

    OMIM
    604611
    Ensembl
    ENSG00000165392
    Entrez Gene
    7486
    UniGene
    632050
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    WRN
    GeneCards
    WRN