Cell Senescence Entries for VEGFA

Cell Types
Dermal endothelial
Cell Lines
Primary cell
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Inhibits
Primary Reference
Watanabe et al. (1997) Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) delays and induces escape from senescence in human dermal microvascular endothelial cells. Oncogene 14(17)2025-32 (PubMed)

VEGFA Gene Information

HGNC symbol
VEGFA 
Aliases
VEGF; VEGF-A; VPF 
Common name
vascular endothelial growth factor A 
Entrez Id
7422
Description
This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site. The levels of VEGF are increased during infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), thus promoting inflammation by facilitating recruitment of inflammatory cells, and by increasing the level of angiopoietin II (Ang II), one of two products of the SARS-CoV-2 binding target, angiotensin-converting enzyme 2 (ACE2). In turn, Ang II facilitates the elevation of VEGF, thus forming a vicious cycle in the release of inflammatory cytokines. [provided by RefSeq, Jun 2020].

VEGFA Ontologies

Gene Ontology
Process: GO:10629; negative regulation of gene expression
GO:43066; negative regulation of apoptotic process
GO:7165; signal transduction
GO:30154; cell differentiation
GO:1934; positive regulation of protein phosphorylation
GO:7399; nervous system development
GO:51781; positive regulation of cell division
GO:1525; angiogenesis
GO:8284; positive regulation of cell population proliferation
GO:45766; positive regulation of angiogenesis
GO:10628; positive regulation of gene expression
And 103 more GO terms
Cellular component: GO:5615; extracellular space
GO:5737; cytoplasm
GO:16020; membrane
GO:5576; extracellular region
GO:31012; extracellular matrix
GO:9986; cell surface
GO:31093; platelet alpha granule lumen
GO:30141; secretory granule
GO:5912; adherens junction
Function: GO:8083; growth factor activity
GO:5515; protein binding
GO:8201; heparin binding
GO:48018; receptor ligand activity
GO:42802; identical protein binding
GO:42803; protein homodimerization activity
GO:5125; cytokine activity
GO:42056; chemoattractant activity
GO:5172; vascular endothelial growth factor receptor binding
GO:43184; vascular endothelial growth factor receptor 2 binding
GO:5161; platelet-derived growth factor receptor binding
And 5 more GO terms
Show all GO terms

Homologs of VEGFA in Model Organisms

Danio rerio
vegfab
Danio rerio
vegfaa
Mus musculus
Vegfa
Rattus norvegicus
Vegfa

In other databases

GenAge human genes
  • This gene is present as VEGFA
LongevityMap
  • This gene is present as VEGFA

External links

OMIM
192240
Ensembl
ENSG00000112715
Entrez Gene
7422
UniGene
73793
1000 Genomes
1000 Genomes
HPRD
GenAtlas
VEGFA
GeneCards
VEGFA