Cell Senescence Entries for TGFB2
- Cell Types
- Lung cancer
- Cell Lines
- A549
- Cancer Cell?
- Yes
- Method
- Knockdown, Mutation, Overexpression
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Gao et al. (2019) Lung cancer deficient in the tumor suppressor GATA4 is sensitive to TGFBR1 inhibition. Nat Commun 10(1)1665 (PubMed)
TGFB2 Gene Information
- HGNC symbol
- TGFB2
- Aliases
- Common name
- transforming growth factor beta 2
- Entrez Id
- 7042
- Description
- This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers. A chromosomal translocation that includes this gene is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. Mutations in this gene may be associated with Loeys-Dietz syndrome. This gene encodes multiple isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016].
TGFB2 Ontologies
- Gene Ontology
-
Process: GO:50778; positive regulation of immune response
GO:51781; positive regulation of cell division
GO:9410; response to xenobiotic stimulus
GO:8284; positive regulation of cell population proliferation
GO:48699; generation of neurons
GO:7507; heart development
GO:30593; neutrophil chemotaxis
GO:8285; negative regulation of cell population proliferation
GO:48666; neuron development
GO:1654; eye development
GO:30509; BMP signaling pathway
And 87 more GO terms Cellular component: GO:5615; extracellular space
GO:5576; extracellular region
GO:30424; axon
GO:62023; collagen-containing extracellular matrix
GO:31093; platelet alpha granule lumen
GO:43025; neuronal cell body
Function: GO:5515; protein binding
GO:8083; growth factor activity
GO:42803; protein homodimerization activity
GO:5102; signaling receptor binding
GO:5160; transforming growth factor beta receptor binding
GO:1540; amyloid-beta binding
GO:5114; type II transforming growth factor beta receptor binding
GO:34714; type III transforming growth factor beta receptor binding
GO:5125; cytokine activity
Homologs of TGFB2 in Model Organisms
In other databases
- GenAge model organism genes
- A homolog of this gene for Drosophila melanogaster is present as daw
- LongevityMap
- This gene is present as TGFB2
- CellAge gene expression
- This gene is present as TGFB2
External links
- OMIM
- 190220
- Ensembl
- ENSG00000092969
- Entrez Gene
- 7042
- UniGene
- 133379
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- TGFB2
- GeneCards
- TGFB2