Cell Senescence Entries for TGFB2

Cell Types
Lung cancer
Cell Lines
A549
Cancer Cell?
Yes
Method
Knockdown, Mutation, Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Gao et al. (2019) Lung cancer deficient in the tumor suppressor GATA4 is sensitive to TGFBR1 inhibition. Nat Commun 10(1)1665 (PubMed)

TGFB2 Gene Information

HGNC symbol
TGFB2 
Aliases
 
Common name
transforming growth factor beta 2 
Entrez Id
7042
Description
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers. A chromosomal translocation that includes this gene is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. Mutations in this gene may be associated with Loeys-Dietz syndrome. This gene encodes multiple isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016].

TGFB2 Ontologies

Gene Ontology
Process: GO:50778; positive regulation of immune response
GO:51781; positive regulation of cell division
GO:9410; response to xenobiotic stimulus
GO:8284; positive regulation of cell population proliferation
GO:48699; generation of neurons
GO:7507; heart development
GO:30593; neutrophil chemotaxis
GO:8285; negative regulation of cell population proliferation
GO:48666; neuron development
GO:1654; eye development
GO:30509; BMP signaling pathway
And 87 more GO terms
Cellular component: GO:5615; extracellular space
GO:5576; extracellular region
GO:30424; axon
GO:62023; collagen-containing extracellular matrix
GO:31093; platelet alpha granule lumen
GO:43025; neuronal cell body
Function: GO:5515; protein binding
GO:8083; growth factor activity
GO:42803; protein homodimerization activity
GO:5102; signaling receptor binding
GO:5160; transforming growth factor beta receptor binding
GO:1540; amyloid-beta binding
GO:5114; type II transforming growth factor beta receptor binding
GO:34714; type III transforming growth factor beta receptor binding
GO:5125; cytokine activity
Show all GO terms

Homologs of TGFB2 in Model Organisms

Danio rerio
tgfb2
Drosophila melanogaster
daw
Mus musculus
Tgfb2
Rattus norvegicus
Tgfb2

In other databases

GenAge model organism genes
  • A homolog of this gene for Drosophila melanogaster is present as daw
LongevityMap
  • This gene is present as TGFB2
CellAge gene expression
  • This gene is present as TGFB2

External links

OMIM
190220
Ensembl
ENSG00000092969
Entrez Gene
7042
UniGene
133379
1000 Genomes
1000 Genomes
HPRD
GenAtlas
TGFB2
GeneCards
TGFB2