Cell Senescence Entries for STAT3
- Cell Types
- Fibroblast
- Cell Lines
- TIG-3
- Cancer Cell?
- No
- Method
- Overexpression
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Induces
- Primary Reference
- Kojima et al. (2012) The STAT3-IGFBP5 axis is critical for IL-6/gp130-induced premature senescence in human fibroblasts. Cell Cycle 11(4)730-9 (PubMed)
STAT3 Gene Information
- HGNC symbol
- STAT3
- Aliases
- APRF
- Common name
- signal transducer and activator of transcription 3
- Entrez Id
- 6774
- Description
- The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. This gene also plays a role in regulating host response to viral and bacterial infections. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. [provided by RefSeq, Aug 2020].
STAT3 Ontologies
- Gene Ontology
-
Process: GO:10628; positive regulation of gene expression
GO:16310; phosphorylation
GO:6355; regulation of transcription, DNA-templated
GO:7165; signal transduction
GO:45893; positive regulation of transcription, DNA-templated
GO:6954; inflammatory response
GO:19221; cytokine-mediated signaling pathway
GO:6357; regulation of transcription by RNA polymerase II
GO:51726; regulation of cell cycle
GO:45944; positive regulation of transcription by RNA polymerase II
GO:6952; defense response
And 56 more GO terms Cellular component: GO:5737; cytoplasm
GO:5634; nucleus
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5886; plasma membrane
GO:785; chromatin
GO:90575; RNA polymerase II transcription regulator complex
GO:5667; transcription regulator complex
Function: GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:31490; chromatin DNA binding
GO:42803; protein homodimerization activity
GO:5515; protein binding
GO:46983; protein dimerization activity
GO:42802; identical protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:140297; DNA-binding transcription factor binding
GO:19901; protein kinase binding
And 10 more GO terms
Homologs of STAT3 in Model Organisms
- Caenorhabditis elegans
- sta-1
- Danio rerio
- stat3
- Drosophila melanogaster
- Stat92E
- Mus musculus
- Stat3
- Rattus norvegicus
- Stat3
In other databases
- GenAge model organism genes
- A homolog of this gene for Drosophila melanogaster is present as Stat92E
- GenAge human genes
- This gene is present as STAT3
- GenAge microarray genes
- This gene is present as STAT3
External links
- OMIM
- 102582
- Ensembl
- ENSG00000168610
- Entrez Gene
- 6774
- UniGene
- 463059
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- STAT3
- GeneCards
- STAT3