Cell Senescence Entries for STAT3

Cell Types
Fibroblast
Cell Lines
TIG-3
Cancer Cell?
No
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Kojima et al. (2012) The STAT3-IGFBP5 axis is critical for IL-6/gp130-induced premature senescence in human fibroblasts. Cell Cycle 11(4)730-9 (PubMed)

STAT3 Gene Information

HGNC symbol
STAT3 
Aliases
APRF 
Common name
signal transducer and activator of transcription 3 
Entrez Id
6774
Description
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. This gene also plays a role in regulating host response to viral and bacterial infections. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. [provided by RefSeq, Aug 2020].

STAT3 Ontologies

Gene Ontology
Process: GO:10628; positive regulation of gene expression
GO:16310; phosphorylation
GO:6355; regulation of transcription, DNA-templated
GO:7165; signal transduction
GO:45893; positive regulation of transcription, DNA-templated
GO:6954; inflammatory response
GO:19221; cytokine-mediated signaling pathway
GO:6357; regulation of transcription by RNA polymerase II
GO:51726; regulation of cell cycle
GO:45944; positive regulation of transcription by RNA polymerase II
GO:6952; defense response
And 56 more GO terms
Cellular component: GO:5737; cytoplasm
GO:5634; nucleus
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5886; plasma membrane
GO:785; chromatin
GO:90575; RNA polymerase II transcription regulator complex
GO:5667; transcription regulator complex
Function: GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:31490; chromatin DNA binding
GO:42803; protein homodimerization activity
GO:5515; protein binding
GO:46983; protein dimerization activity
GO:42802; identical protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:140297; DNA-binding transcription factor binding
GO:19901; protein kinase binding
And 10 more GO terms
Show all GO terms

Homologs of STAT3 in Model Organisms

Caenorhabditis elegans
sta-1
Danio rerio
stat3
Drosophila melanogaster
Stat92E
Mus musculus
Stat3
Rattus norvegicus
Stat3

In other databases

GenAge model organism genes
  • A homolog of this gene for Drosophila melanogaster is present as Stat92E
GenAge human genes
  • This gene is present as STAT3
GenAge microarray genes
  • This gene is present as STAT3

External links

OMIM
102582
Ensembl
ENSG00000168610
Entrez Gene
6774
UniGene
463059
1000 Genomes
1000 Genomes
HPRD
GenAtlas
STAT3
GeneCards
STAT3