Cell Senescence Entries for SLC13A3

Cell Types
Lung fibroblast, Renal tubular
Cell Lines
MRC-5, WI-38
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Induces
Observations
Overexpression of NaDC3 ( SLC13A3) accelerated cellular senescence in young human diploid cells (MRC-5 and WI-38) and primary renal tubular cells, leading to cell cycle arrest in G1 phase and increased expression of senescence biomarkers: SA-beta-galactosidase and p16.
Primary Reference

    SLC13A3 Gene Information

    HGNC symbol
    SLC13A3 
    Aliases
    NADC3; SDCT2 
    Common name
    solute carrier family 13 member 3 
    Entrez Id
    64849
    Description
    Mammalian sodium-dicarboxylate cotransporters transport succinate and other Krebs cycle intermediates. They fall into 2 categories based on their substrate affinity: low affinity and high affinity. Both the low- and high-affinity transporters play an important role in the handling of citrate by the kidneys. The protein encoded by this gene represents the high-affinity form. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been characterized yet. [provided by RefSeq, Jul 2008]

    SLC13A3 Ontologies

    Gene Ontology
    Process: GO:15746; citrate transport
    GO:6814; sodium ion transport
    GO:71422; succinate transmembrane transport
    Cellular component: GO:70062; extracellular exosome
    GO:5887; integral component of plasma membrane
    GO:5886; plasma membrane
    Function: GO:15137; citrate transmembrane transporter activity
    GO:15362; high-affinity sodium:dicarboxylate symporter activity
    GO:17153; sodium:dicarboxylate symporter activity
    GO:15141; succinate transmembrane transporter activity
    Show all GO terms

    Homologs of SLC13A3 in Model Organisms

    Caenorhabditis elegans
    nac-3
    Caenorhabditis elegans
    nac-1
    Danio rerio
    slc13a3
    Drosophila melanogaster
    CG33934
    Drosophila melanogaster
    Indy-2
    Drosophila melanogaster
    CG7309
    Drosophila melanogaster
    Indy
    Mus musculus
    Slc13a3
    Rattus norvegicus
    Slc13a3
    Schizosaccharomyces pombe
    SPBC3B8.04c

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Drosophila melanogaster is present as Indy
    • A homolog of this gene for Caenorhabditis elegans is present as nac-3
    GenDR gene manipulations
    • A homolog of this gene for Drosophila melanogaster is present as Indy

    External links

    OMIM
    606411
    Ensembl
    ENSG00000158296
    Entrez Gene
    64849
    UniGene
    655498
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    SLC13A3
    GeneCards
    SLC13A3