Cell Senescence Entries for SIK1

Cell Types
Embryonic kidney, Lung fibroblast
Cell Lines
HEK293T, IMR-90, MRC-5
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Induces
Observations
A library of 200 constitutively activated kinases was screened in order to identify kinases whose constitutive expression decreased cell proliferation and induced expression of senescence markers; p16 and SASP components. A total of 33 kinases showed pro-senescence effects (particularly MAP3K7, PRKCD, and MATK); kinases with strong pro-senescence effects, induced expression of SASP-component genes (e.g. IL1A, IL1B, IL6 and IL8) through activation of an NF-kappaB-dependent transcriptional program. Inhibition of the NF-kappaB, p53, or Rb pathway proved insufficient to prevent kinase-triggered cell cycle arrest.
Primary Reference

    SIK1 Gene Information

    HGNC symbol
    SIK1 
    Aliases
    MSK; SIK; SIK-1; SNF1LK 
    Common name
    salt inducible kinase 1 
    Entrez Id
    150094
    Description
    This gene encodes a serine/threonine protein kinase that contains a ubiquitin-associated (UBA) domain. The encoded protein is a member of the adenosine monophosphate-activated kinase (AMPK) subfamily of kinases that play a role in conserved signal transduction pathways. A mutation in this gene is associated with early infantile epileptic encephalopathy 30. [provided by RefSeq, Nov 2016]

    SIK1 Ontologies

    Gene Ontology
    Process: GO:55007; cardiac muscle cell differentiation
    GO:7049; cell cycle
    GO:32870; cellular response to hormone stimulus
    GO:43153; entrainment of circadian clock by photoperiod
    GO:35556; intracellular signal transduction
    GO:32792; negative regulation of CREB transcription factor activity
    GO:45721; negative regulation of gluconeogenesis
    GO:10868; negative regulation of triglyceride biosynthetic process
    GO:2000210; positive regulation of anoikis
    GO:46777; protein autophosphorylation
    GO:6468; protein phosphorylation
    And 6 more GO terms
    Cellular component: GO:5737; cytoplasm
    GO:5634; nucleus
    Function: GO:71889; 14-3-3 protein binding
    GO:5524; ATP binding
    GO:8140; cAMP response element binding protein binding
    GO:287; magnesium ion binding
    GO:5515; protein binding
    GO:19901; protein kinase binding
    GO:4674; protein serine/threonine kinase activity
    Show all GO terms

    Homologs of SIK1 in Model Organisms

    Caenorhabditis elegans
    kin-29
    Danio rerio
    sik1
    Drosophila melanogaster
    Sik2
    Mus musculus
    Sik1
    Rattus norvegicus
    Sik1
    Saccharomyces cerevisiae
    SNF1

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Saccharomyces cerevisiae is present as SNF1

    External links

    OMIM
    605705
    Ensembl
    ENSG00000142178
    Entrez Gene
    150094
    UniGene
    282113
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    SIK1
    GeneCards
    SIK1