Cell Senescence Entries for RRM2

Cell Types
Melanoma
Cell Lines
SK-MEL-19, SK-MEL-29
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Mannava et al. (2013) Ribonucleotide reductase and thymidylate synthase or exogenous deoxyribonucleosides reduce DNA damage and senescence caused by C-MYC depletion. Aging (Albany NY) 4(12)917-22 (PubMed)

RRM2 Gene Information

HGNC symbol
RRM2 
Aliases
C2orf48; FLJ25102 
Common name
ribonucleotide reductase regulatory subunit M2 
Entrez Id
6241
Description
This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Sep 2009].

RRM2 Ontologies

Gene Ontology
Process: GO:6260; DNA replication
GO:9263; deoxyribonucleotide biosynthetic process
GO:9185; ribonucleoside diphosphate metabolic process
GO:9265; 2'-deoxyribonucleotide biosynthetic process
GO:1900087; positive regulation of G1/S transition of mitotic cell cycle
GO:1824; blastocyst development
GO:9262; deoxyribonucleotide metabolic process
GO:51290; protein heterotetramerization
GO:55086; nucleobase-containing small molecule metabolic process
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5829; cytosol
GO:5971; ribonucleoside-diphosphate reductase complex
Function: GO:46872; metal ion binding
GO:16491; oxidoreductase activity
GO:5515; protein binding
GO:4748; ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:8199; ferric iron binding
GO:42802; identical protein binding
GO:42803; protein homodimerization activity
Show all GO terms

Homologs of RRM2 in Model Organisms

Caenorhabditis elegans
rnr-2
Danio rerio
rrm2
Danio rerio
rrm2
Drosophila melanogaster
RnrS
Mus musculus
Rrm2
Rattus norvegicus
Rrm2
Rattus norvegicus
LOC100359539
Saccharomyces cerevisiae
RNR2

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as rnr-2
CellAge gene expression
  • This gene is present as RRM2

External links

OMIM
180390
Ensembl
ENSG00000171848
Entrez Gene
6241
UniGene
226390
1000 Genomes
1000 Genomes
HPRD
GenAtlas
RRM2
GeneCards
RRM2