Cell Senescence Entries for RAF1
- Cell Types
- Lung fibroblast
- Cell Lines
- IMR-90
- Cancer Cell?
- No
- Method
- Overexpression
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Induces
- Primary Reference
- Zhu et al. (1998) Senescence of human fibroblasts induced by oncogenic Raf. Genes Dev 12(19)2997-3007 (PubMed)
RAF1 Gene Information
- HGNC symbol
- RAF1
- Aliases
- c-Raf; CRAF; Raf-1
- Common name
- Raf-1 proto-oncogene, serine/threonine kinase
- Entrez Id
- 5894
- Description
- This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008].
RAF1 Ontologies
- Gene Ontology
-
Process: GO:6468; protein phosphorylation
GO:43066; negative regulation of apoptotic process
GO:7165; signal transduction
GO:1934; positive regulation of protein phosphorylation
GO:1902531; regulation of intracellular signal transduction
GO:16310; phosphorylation
GO:42981; regulation of apoptotic process
GO:33138; positive regulation of peptidyl-serine phosphorylation
GO:45595; regulation of cell differentiation
GO:31333; negative regulation of protein-containing complex assembly
GO:43154; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
And 22 more GO terms Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5829; cytosol
GO:5886; plasma membrane
GO:5739; mitochondrion
GO:5794; Golgi apparatus
GO:5741; mitochondrial outer membrane
GO:31143; pseudopodium
Function: GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:5524; ATP binding
GO:5515; protein binding
GO:46872; metal ion binding
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:19899; enzyme binding
And 4 more GO terms
Homologs of RAF1 in Model Organisms
- Caenorhabditis elegans
- lin-45
- Danio rerio
- raf1b
- Danio rerio
- raf1a
- Drosophila melanogaster
- phl
- Mus musculus
- Raf1
- Rattus norvegicus
- Raf1
In other databases
- LongevityMap
- This gene is present as RAF1
External links
- OMIM
- 164760
- Ensembl
- ENSG00000132155
- Entrez Gene
- 5894
- UniGene
- 159130
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- RAF1
- GeneCards
- RAF1