Cell Senescence Entries for PRKN
- Cell Types
- Bronchial epithelial
- Cell Lines
- BEAS-2B
- Cancer Cell?
- No
- Method
- Knockdown
- Type of senescence
- Stress-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Ito et al. (2016) PARK2-mediated mitophagy is involved in regulation of HBEC senescence in COPD pathogenesis. Autophagy 11(3)547-59 (PubMed)
PRKN Gene Information
- HGNC symbol
- PRKN
- Aliases
- AR-JP; PARK2; parkin; PDJ
- Common name
- parkin RBR E3 ubiquitin protein ligase
- Entrez Id
- 5071
- Description
- The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support. [provided by RefSeq, Jul 2008].
PRKN Ontologies
- Gene Ontology
-
Process: GO:16567; protein ubiquitination
GO:6914; autophagy
GO:50896; response to stimulus
GO:51865; protein autoubiquitination
GO:85020; protein K6-linked ubiquitination
GO:6511; ubiquitin-dependent protein catabolic process
GO:209; protein polyubiquitination
GO:6464; cellular protein modification process
GO:70936; protein K48-linked ubiquitination
GO:31648; protein destabilization
GO:50821; protein stabilization
And 102 more GO terms Cellular component: GO:5737; cytoplasm
GO:5634; nucleus
GO:16607; nuclear speck
GO:16020; membrane
GO:5794; Golgi apparatus
GO:5783; endoplasmic reticulum
GO:5829; cytosol
GO:5739; mitochondrion
GO:98793; presynapse
GO:5741; mitochondrial outer membrane
GO:30054; cell junction
And 12 more GO terms Function: GO:5515; protein binding
GO:46872; metal ion binding
GO:16740; transferase activity
GO:31625; ubiquitin protein ligase binding
GO:4842; ubiquitin-protein transferase activity
GO:61630; ubiquitin protein ligase activity
GO:43130; ubiquitin binding
GO:42802; identical protein binding
GO:19901; protein kinase binding
GO:51087; chaperone binding
GO:30544; Hsp70 protein binding
And 20 more GO terms
Homologs of PRKN in Model Organisms
- Caenorhabditis elegans
- pdr-1
- Danio rerio
- park2
- Drosophila melanogaster
- park
- Mus musculus
- Park2
- Rattus norvegicus
- AC135026.1
- Rattus norvegicus
- AABR07001519.1
In other databases
- GenAge model organism genes
- A homolog of this gene for Drosophila melanogaster is present as park
- LongevityMap
- This gene is present as PRKN
External links
- OMIM
- 602544
- Ensembl
- ENSG00000185345
- Entrez Gene
- 5071
- UniGene
- 132954
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- PRKN
- GeneCards
- PRKN