Cell Senescence Entries for PRKN

Cell Types
Bronchial epithelial
Cell Lines
BEAS-2B
Cancer Cell?
No
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Ito et al. (2016) PARK2-mediated mitophagy is involved in regulation of HBEC senescence in COPD pathogenesis. Autophagy 11(3)547-59 (PubMed)

PRKN Gene Information

HGNC symbol
PRKN 
Aliases
AR-JP; PARK2; parkin; PDJ 
Common name
parkin RBR E3 ubiquitin protein ligase 
Entrez Id
5071
Description
The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support. [provided by RefSeq, Jul 2008].

PRKN Ontologies

Gene Ontology
Process: GO:16567; protein ubiquitination
GO:6914; autophagy
GO:50896; response to stimulus
GO:51865; protein autoubiquitination
GO:85020; protein K6-linked ubiquitination
GO:6511; ubiquitin-dependent protein catabolic process
GO:209; protein polyubiquitination
GO:6464; cellular protein modification process
GO:70936; protein K48-linked ubiquitination
GO:31648; protein destabilization
GO:50821; protein stabilization
And 102 more GO terms
Cellular component: GO:5737; cytoplasm
GO:5634; nucleus
GO:16607; nuclear speck
GO:16020; membrane
GO:5794; Golgi apparatus
GO:5783; endoplasmic reticulum
GO:5829; cytosol
GO:5739; mitochondrion
GO:98793; presynapse
GO:5741; mitochondrial outer membrane
GO:30054; cell junction
And 12 more GO terms
Function: GO:5515; protein binding
GO:46872; metal ion binding
GO:16740; transferase activity
GO:31625; ubiquitin protein ligase binding
GO:4842; ubiquitin-protein transferase activity
GO:61630; ubiquitin protein ligase activity
GO:43130; ubiquitin binding
GO:42802; identical protein binding
GO:19901; protein kinase binding
GO:51087; chaperone binding
GO:30544; Hsp70 protein binding
And 20 more GO terms
Show all GO terms

Homologs of PRKN in Model Organisms

Caenorhabditis elegans
pdr-1
Danio rerio
park2
Drosophila melanogaster
park
Mus musculus
Park2
Rattus norvegicus
AC135026.1
Rattus norvegicus
AABR07001519.1

In other databases

GenAge model organism genes
  • A homolog of this gene for Drosophila melanogaster is present as park
LongevityMap
  • This gene is present as PRKN

External links

OMIM
602544
Ensembl
ENSG00000185345
Entrez Gene
5071
UniGene
132954
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PRKN
GeneCards
PRKN