The PPP2R1A gene and its putative association with human ageing

Cell Senescence Entries for PPP2R1A

Cell Types: Lung cancer
Cell Lines: NCI-H460
Cancer Cell?: Yes
Method: Mutation
Type of senescence: Oncogene-induced
Senescence Effect: Induces
Primary Reference: Kauko et al. (2019) PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells. Sci Transl Med 10(450)117-26 (PubMed)

PPP2R1A Gene Information

HGNC symbol: PPP2R1A
Aliases: PP2A-Aalpha; PP2AA; PR65A
Common name: protein phosphatase 2 scaffold subunit Aalpha
Entrez Id: 5518
Description: This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010].

PPP2R1A Ontologies

Gene Ontology

Process:

GO:8380; RNA splicing
GO:6915; apoptotic process
GO:50790; regulation of catalytic activity
GO:6355; regulation of transcription, DNA-templated
GO:40008; regulation of growth
GO:6470; protein dephosphorylation
GO:10033; response to organic substance
GO:7059; chromosome segregation
GO:6672; ceramide metabolic process
GO:65003; protein-containing complex assembly
GO:30111; regulation of Wnt signaling pathway

And 15 more GO terms

Cellular component:	GO:5634; nucleus GO:5737; cytoplasm GO:16020; membrane GO:5886; plasma membrane GO:5739; mitochondrion GO:5829; cytosol GO:5694; chromosome GO:42995; cell projection GO:30425; dendrite GO:43005; neuron projection GO:775; chromosome, centromeric region
	And 8 more GO terms

Function:

GO:5515; protein binding
GO:19888; protein phosphatase regulator activity
GO:4722; protein serine/threonine phosphatase activity
GO:46982; protein heterodimerization activity
GO:1990405; protein antigen binding

Show all GO terms

Homologs of PPP2R1A in Model Organisms

Caenorhabditis elegans: paa-1
Drosophila melanogaster: Pp2A-29B
Mus musculus: Ppp2r1a
Rattus norvegicus: Ppp2r1a
Saccharomyces cerevisiae: TPD3

Cell Senescence Entries for PPP2R1A

PPP2R1A Gene Information

PPP2R1A Ontologies

Homologs of PPP2R1A in Model Organisms

External links