Cell Senescence Entries for NUAK1

Cell Types
Lung fibroblast
Cell Lines
WI-38
Cancer Cell?
No
Method
Knockout, Overexpression
Type of senescence
Replicative
Senescence Effect
Induces
Observations
Knockdown of the AMPK-related protein kinase 5 (NUAK1) resulted in an extension of cellular replicative lifespan in normal human diploid fibroblasts. In contrast, ectopic expression of NUAK1 triggered premature senescence.
Primary Reference

    NUAK1 Gene Information

    HGNC symbol
    NUAK1 
    Aliases
    ARK5 
    Common name
    NUAK family kinase 1 
    Entrez Id
    9891
    Description

    NUAK1 Ontologies

    Gene Ontology
    Process: GO:7155; cell adhesion
    GO:6974; cellular response to DNA damage stimulus
    GO:35556; intracellular signal transduction
    GO:6468; protein phosphorylation
    GO:30155; regulation of cell adhesion
    GO:42127; regulation of cell proliferation
    GO:2000772; regulation of cellular senescence
    GO:35507; regulation of myosin-light-chain-phosphatase activity
    GO:1901796; regulation of signal transduction by p53 class mediator
    Cellular component: GO:5737; cytoplasm
    GO:1650; fibrillar center
    GO:15630; microtubule cytoskeleton
    GO:5654; nucleoplasm
    GO:5634; nucleus
    Function: GO:5524; ATP binding
    GO:46872; metal ion binding
    GO:2039; p53 binding
    GO:5515; protein binding
    GO:4674; protein serine/threonine kinase activity
    Show all GO terms

    Homologs of NUAK1 in Model Organisms

    Caenorhabditis elegans
    unc-82
    Danio rerio
    nuak1b
    Danio rerio
    nuak1a
    Drosophila melanogaster
    CG43143
    Mus musculus
    Nuak1
    Rattus norvegicus
    Nuak1
    Saccharomyces cerevisiae
    SNF1

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Saccharomyces cerevisiae is present as SNF1
    CellAge gene expression
    • This gene is present as NUAK1

    External links

    OMIM
    608130
    Ensembl
    ENSG00000074590
    Entrez Gene
    9891
    UniGene
    524692
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    NUAK1
    GeneCards
    NUAK1