Cell Senescence Entries for NRF1

Cell Types
Mammary epithelial
Cell Lines
MCF-10A
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Das et al. (2020) Nuclear Respiratory Factor 1 Acting as an Oncoprotein Drives Estrogen-Induced Breast Carcinogenesis. Cells 7(12)117-26 (PubMed)

NRF1 Gene Information

HGNC symbol
NRF1 
Aliases
ALPHA-PAL; EWG 
Common name
nuclear respiratory factor 1 
Entrez Id
4899
Description
This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternative splicing results in multiple transcript variants. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for 'nuclear factor (erythroid-derived 2)-like 1' which has an official symbol of NFE2L1. [provided by RefSeq, May 2014].

NRF1 Ontologies

Gene Ontology
Process: GO:6357; regulation of transcription by RNA polymerase II
GO:45944; positive regulation of transcription by RNA polymerase II
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:5829; cytosol
GO:70062; extracellular exosome
Function: GO:3700; DNA-binding transcription factor activity
GO:3677; DNA binding
GO:5515; protein binding
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:42803; protein homodimerization activity
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
Show all GO terms

Homologs of NRF1 in Model Organisms

Danio rerio
nrf1
Drosophila melanogaster
ewg
Mus musculus
Nrf1
Rattus norvegicus
Nrf1

In other databases

LongevityMap
  • This gene is present as NRF1

External links

OMIM
600879
Ensembl
ENSG00000106459
Entrez Gene
4899
UniGene
654363
1000 Genomes
1000 Genomes
HPRD
GenAtlas
NRF1
GeneCards
NRF1