Cell Senescence Entries for NDRG1

Cell Types
Liver cancer
Cell Lines
Hep G2, Hep3B, Huh7, PLC/PRF/5
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Lu et al. (2014) Suppressing N-Myc downstream regulated gene 1 reactivates senescence signaling and inhibits tumor growth in hepatocellular carcinoma. Carcinogenesis 35(4)915-22 (PubMed)

NDRG1 Gene Information

HGNC symbol
NDRG1 
Aliases
CAP43; DRG1; NDR1; RTP; TDD5 
Common name
N-myc downstream regulated 1 
Entrez Id
10397
Description
This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. The encoded protein is necessary for p53-mediated caspase activation and apoptosis. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4D, and expression of this gene may be a prognostic indicator for several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012].

NDRG1 Ontologies

Gene Ontology
Process: GO:7165; signal transduction
GO:42127; regulation of cell population proliferation
GO:32287; peripheral nervous system myelin maintenance
GO:45576; mast cell activation
GO:30330; DNA damage response, signal transduction by p53 class mediator
GO:71456; cellular response to hypoxia
GO:10038; response to metal ion
GO:8285; negative regulation of cell population proliferation
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5829; cytosol
GO:5886; plasma membrane
GO:5856; cytoskeleton
GO:5912; adherens junction
GO:15630; microtubule cytoskeleton
GO:5874; microtubule
GO:48471; perinuclear region of cytoplasm
GO:55038; recycling endosome membrane
And 4 more GO terms
Function: GO:5515; protein binding
GO:8017; microtubule binding
GO:45296; cadherin binding
GO:31267; small GTPase binding
GO:43015; gamma-tubulin binding
Show all GO terms

Homologs of NDRG1 in Model Organisms

Caenorhabditis elegans
ZK1073.1
Caenorhabditis elegans
Y48G10A.3
Danio rerio
ndrg1a
Danio rerio
ndrg1b
Drosophila melanogaster
MESK2
Drosophila melanogaster
CG2082
Mus musculus
Ndrg1
Rattus norvegicus
Ndrg1

In other databases

GenAge microarray genes
  • This gene is present as NDRG1
CellAge gene expression
  • This gene is present as NDRG1

External links

OMIM
605262
Ensembl
ENSG00000104419
Entrez Gene
10397
UniGene
618002
1000 Genomes
1000 Genomes
HPRD
GenAtlas
NDRG1
GeneCards
NDRG1