Cell Senescence Entries for MAP3K14

Cell Types
Cervical cancer
Cell Lines
HeLa
Cancer Cell?
Yes
Method
Knockdown, Mutation
Type of senescence
Stress-induced
Senescence Effect
Induces
Primary Reference
Ho et al. (2012) HTLV-1 tax-induced rapid senescence is driven by the transcriptional activity of NF-κB and depends on chronically activated IKKα and p65/RelA. J Virol 86(17)9474-83 (PubMed)

MAP3K14 Gene Information

HGNC symbol
MAP3K14 
Aliases
FTDCR1B; HS; HSNIK; NIK 
Common name
mitogen-activated protein kinase kinase kinase 14 
Entrez Id
9020
Description
This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq, Jul 2008].

MAP3K14 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:165; MAPK cascade
GO:43123; positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:51607; defense response to virus
GO:6955; immune response
GO:71260; cellular response to mechanical stimulus
GO:7249; I-kappaB kinase/NF-kappaB signaling
GO:38061; NIK/NF-kappaB signaling
Cellular component: GO:5737; cytoplasm
GO:43231; intracellular membrane-bounded organelle
GO:5654; nucleoplasm
GO:5829; cytosol
GO:1650; fibrillar center
Function: GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:5515; protein binding
GO:4709; MAP kinase kinase kinase activity
GO:4704; NF-kappaB-inducing kinase activity
And 1 more GO terms
Show all GO terms

Homologs of MAP3K14 in Model Organisms

Danio rerio
map3k14a
Danio rerio
map3k14b
Mus musculus
Map3k14
Rattus norvegicus
Map3k14
Saccharomyces cerevisiae
STE11
Saccharomyces cerevisiae
BCK1

In other databases

GenAge model organism genes
  • A homolog of this gene for Saccharomyces cerevisiae is present as BCK1
  • A homolog of this gene for Saccharomyces cerevisiae is present as STE11

External links

OMIM
604655
Ensembl
ENSG00000006062
Entrez Gene
9020
UniGene
668927
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MAP3K14
GeneCards
MAP3K14