Cell Senescence Entries for MAP2K1
- Cell Types
- Intestinal epithelial
- Cell Lines
- HIEC-6
- Cancer Cell?
- No
- Method
- Overexpression
- Type of senescence
- Unclear
- Senescence Effect
- Induces
- Primary Reference
- Boucher et al. (2004) Dual role of MEK/ERK signaling in senescence and transformation of intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol 286(5)G736-46 (PubMed)
MAP2K1 Gene Information
- HGNC symbol
- MAP2K1
- Aliases
- MAPKK1; MEK1; PRKMK1
- Common name
- mitogen-activated protein kinase kinase 1
- Entrez Id
- 5604
- Description
- The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq, Jul 2008].
MAP2K1 Ontologies
- Gene Ontology
-
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:18108; peptidyl-tyrosine phosphorylation
GO:32147; activation of protein kinase activity
GO:71902; positive regulation of protein serine/threonine kinase activity
GO:10628; positive regulation of gene expression
GO:7507; heart development
GO:21697; cerebellar cortex formation
GO:30182; neuron differentiation
GO:30216; keratinocyte differentiation
GO:30878; thyroid gland development
And 26 more GO terms Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5794; Golgi apparatus
GO:5829; cytosol
GO:5886; plasma membrane
GO:5770; late endosome
GO:5739; mitochondrion
GO:5856; cytoskeleton
GO:5925; focal adhesion
GO:5769; early endosome
And 3 more GO terms
Show all GO termsFunction: GO:5524; ATP binding
GO:4672; protein kinase activity
GO:166; nucleotide binding
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:4713; protein tyrosine kinase activity
GO:5515; protein binding
GO:43539; protein serine/threonine kinase activator activity
And 7 more GO terms
Homologs of MAP2K1 in Model Organisms
- Caenorhabditis elegans
- mek-2
- Danio rerio
- map2k1
- Drosophila melanogaster
- Dsor1
- Mus musculus
- Map2k1
- Rattus norvegicus
- Map2k1
- Saccharomyces cerevisiae
- PBS2
- Schizosaccharomyces pombe
- byr1
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as mek-2
- LongevityMap
- This gene is present as MAP2K1
External links
- OMIM
- 176872
- Ensembl
- ENSG00000169032
- Entrez Gene
- 5604
- UniGene
- 677223
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- MAP2K1
- GeneCards
- MAP2K1