Cell Senescence Entries for KL
- Cell Types
- Lung fibroblast
- Cell Lines
- MRC-5, WI-38
- Cancer Cell?
- No
- Method
- Knockdown
- Type of senescence
- Replicative
- Senescence Effect
- Inhibits
- Observations
- Downregulation of Klotho (KL) by RNA interference up-regulated p21 expression, induced a flattened and enlarged cell morphology and led to an increased SA-beta-galactosidase activity, ultimately shortening replicative lifespan and reducing the growth rate of lung fibroblasts.
- Primary Reference
KL Gene Information
- HGNC symbol
- KL
- Aliases
- Common name
- klotho
- Entrez Id
- 9365
- Description
- This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss. [provided by RefSeq, Jul 2008]
KL Ontologies
- Gene Ontology
-
Process: GO:165; MAPK cascade
GO:7568; aging
GO:55074; calcium ion homeostasis
GO:5975; carbohydrate metabolic process
GO:6112; energy reserve metabolic process
GO:8543; fibroblast growth factor receptor signaling pathway
GO:1901657; glycosyl compound metabolic process
GO:8286; insulin receptor signaling pathway
GO:46854; phosphatidylinositol phosphorylation
GO:36092; phosphatidylinositol-3-phosphate biosynthetic process
GO:48015; phosphatidylinositol-mediated signaling
And 5 more GO terms Cellular component: GO:16324; apical plasma membrane
GO:70062; extracellular exosome
GO:5576; extracellular region
GO:5615; extracellular space
GO:5887; integral component of plasma membrane
GO:5622; intracellular
GO:5886; plasma membrane
Function: GO:16303; 1-phosphatidylinositol-3-kinase activity
GO:5088; Ras guanyl-nucleotide exchange factor activity
GO:8422; beta-glucosidase activity
GO:4566; beta-glucuronidase activity
GO:17134; fibroblast growth factor binding
GO:5104; fibroblast growth factor receptor binding
GO:5179; hormone activity
GO:46934; phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:4871; signal transducer activity
GO:5499; vitamin D binding
Homologs of KL in Model Organisms
- Caenorhabditis elegans
- klo-2
- Caenorhabditis elegans
- klo-1
- Danio rerio
- kl
- Mus musculus
- Kl
- Rattus norvegicus
- Kl
In other databases
- GenAge model organism genes
- GenAge human genes
- This gene is present as KL
- LongevityMap
- This gene is present as KL
External links
- OMIM
- 604824
- Ensembl
- ENSG00000133116
- Entrez Gene
- 9365
- UniGene
- 524953
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- KL
- GeneCards
- KL