Cell Senescence Entries for HRAS
- Cell Types
- Lung fibroblast
- Cell Lines
- IMR-90, WI-38
- Cancer Cell?
- No
- Method
- Overexpression
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Induces
- Primary Reference
- Serrano et al. (1997) Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88(5)593-602 (PubMed)
HRAS Gene Information
- HGNC symbol
- HRAS
- Aliases
- HRAS1
- Common name
- HRas proto-oncogene, GTPase
- Entrez Id
- 3265
- Description
- This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, cognitive disability, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. [provided by RefSeq, Jul 2008].
HRAS Ontologies
- Gene Ontology
-
Process: GO:7165; signal transduction
GO:90314; positive regulation of protein targeting to membrane
GO:8284; positive regulation of cell population proliferation
GO:45944; positive regulation of transcription by RNA polymerase II
GO:2000251; positive regulation of actin cytoskeleton reorganization
GO:6935; chemotaxis
GO:30335; positive regulation of cell migration
GO:43547; positive regulation of GTPase activity
GO:43406; positive regulation of MAP kinase activity
GO:7166; cell surface receptor signaling pathway
GO:6357; regulation of transcription by RNA polymerase II
And 34 more GO terms Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5794; Golgi apparatus
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5886; plasma membrane
GO:139; Golgi membrane
GO:48471; perinuclear region of cytoplasm
GO:5789; endoplasmic reticulum membrane
GO:98978; glutamatergic synapse
And 2 more GO terms Function: GO:166; nucleotide binding
GO:16787; hydrolase activity
GO:3924; GTPase activity
GO:5525; GTP binding
GO:3925; G protein activity
GO:5515; protein binding
GO:8022; protein C-terminus binding
GO:19003; GDP binding
Homologs of HRAS in Model Organisms
- Caenorhabditis elegans
- let-60
- Danio rerio
- hrasb
- Danio rerio
- hrasa
- Drosophila melanogaster
- Ras85D
- Mus musculus
- Hras
- Rattus norvegicus
- Hras
- Rattus norvegicus
- Hras
- Saccharomyces cerevisiae
- RAS2
- Saccharomyces cerevisiae
- RAS1
In other databases
- GenAge model organism genes
- GenAge human genes
- This gene is present as HRAS
- LongevityMap
- This gene is present as HRAS
External links
- OMIM
- 190020
- Ensembl
- ENSG00000174775
- Entrez Gene
- 3265
- UniGene
- 37003
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- HRAS
- GeneCards
- HRAS