Cell Senescence Entries for HK3
- Cell Types
- Embryonic kidney, Lung fibroblast
- Cell Lines
- HEK293T, IMR-90, MRC-5
- Cancer Cell?
- No
- Method
- Overexpression
- Type of senescence
- Unclear
- Senescence Effect
- Induces
- Primary Reference
- Ferrand et al. (2016) Screening of a kinase library reveals novel pro-senescence kinases and their common NF-κB-dependent transcriptional program. Aging (Albany NY) 7(11)986-1003 (PubMed)
HK3 Gene Information
- HGNC symbol
- HK3
- Aliases
- Common name
- hexokinase 3
- Entrez Id
- 3101
- Description
- Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by its product glucose-6-phosphate. [provided by RefSeq, Apr 2009].
HK3 Ontologies
- Gene Ontology
-
Process: GO:16310; phosphorylation
GO:6096; glycolytic process
GO:1678; cellular glucose homeostasis
GO:5975; carbohydrate metabolic process
GO:19318; hexose metabolic process
GO:46835; carbohydrate phosphorylation
GO:51156; glucose 6-phosphate metabolic process
GO:8152; metabolic process
GO:6002; fructose 6-phosphate metabolic process
GO:61621; canonical glycolysis
Cellular component: GO:5576; extracellular region
GO:5739; mitochondrion
GO:5829; cytosol
GO:34774; secretory granule lumen
GO:1904813; ficolin-1-rich granule lumen
Function: GO:166; nucleotide binding
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:4340; glucokinase activity
GO:4396; hexokinase activity
GO:5536; glucose binding
GO:16773; phosphotransferase activity, alcohol group as acceptor
GO:3824; catalytic activity
GO:5515; protein binding
GO:8865; fructokinase activity
And 2 more GO terms
Homologs of HK3 in Model Organisms
- Caenorhabditis elegans
- hxk-1
- Drosophila melanogaster
- Hex-A
- Drosophila melanogaster
- Hex-t1
- Drosophila melanogaster
- Hex-C
- Drosophila melanogaster
- Hex-t2
- Mus musculus
- Hk3
- Rattus norvegicus
- Hk3
- Saccharomyces cerevisiae
- HXK2
- Saccharomyces cerevisiae
- GLK1
In other databases
- GenAge model organism genes
- GenDR gene manipulations
External links
- OMIM
- 142570
- Ensembl
- ENSG00000160883
- Entrez Gene
- 3101
- UniGene
- 411695
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- HK3
- GeneCards
- HK3