Cell Senescence Entries for HK3
- Cell Types
- Embryonic kidney, Lung fibroblast
- Cell Lines
- HEK293T, IMR-90, MRC-5
- Cancer Cell?
- No
- Method
- Overexpression
- Type of senescence
- Replicative
- Senescence Effect
- Induces
- Observations
- A library of 200 constitutively activated kinases was screened in order to identify kinases whose constitutive expression decreased cell proliferation and induced expression of senescence markers; p16 and SASP components. A total of 33 kinases showed pro-senescence effects (particularly MAP3K7, PRKCD, and MATK); kinases with strong pro-senescence effects, induced expression of SASP-component genes (e.g. IL1A, IL1B, IL6 and IL8) through activation of an NF-kappaB-dependent transcriptional program. Inhibition of the NF-kappaB, p53, or Rb pathway proved insufficient to prevent kinase-triggered cell cycle arrest.
- Primary Reference
HK3 Gene Information
- HGNC symbol
- HK3
- Aliases
- HXK3; HKIII
- Common name
- hexokinase 3
- Entrez Id
- 3101
- Description
- Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by its product glucose-6-phosphate. [provided by RefSeq, Apr 2009]
HK3 Ontologies
- Gene Ontology
-
Process: GO:61621; canonical glycolysis
GO:46835; carbohydrate phosphorylation
GO:1678; cellular glucose homeostasis
GO:51156; glucose 6-phosphate metabolic process
GO:15758; glucose transport
GO:6096; glycolytic process
GO:43312; neutrophil degranulation
Cellular component: GO:5829; cytosol
GO:5576; extracellular region
GO:1904813; ficolin-1-rich granule lumen
GO:5739; mitochondrion
GO:34774; secretory granule lumen
Function: GO:5524; ATP binding
GO:8865; fructokinase activity
GO:4340; glucokinase activity
GO:5536; glucose binding
GO:4396; hexokinase activity
GO:19158; mannokinase activity
Homologs of HK3 in Model Organisms
- Caenorhabditis elegans
- hxk-1
- Drosophila melanogaster
- Hex-A
- Drosophila melanogaster
- Hex-t1
- Drosophila melanogaster
- Hex-C
- Drosophila melanogaster
- Hex-t2
- Mus musculus
- Hk3
- Rattus norvegicus
- Hk3
- Saccharomyces cerevisiae
- HXK2
- Saccharomyces cerevisiae
- GLK1
In other databases
- GenAge model organism genes
- GenDR gene manipulations
External links
- OMIM
- 142570
- Ensembl
- ENSG00000160883
- Entrez Gene
- 3101
- UniGene
- 411695
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- HK3
- GeneCards
- HK3