Cell Senescence Entries for HK3

Cell Types
Embryonic kidney, Lung fibroblast
Cell Lines
HEK293T, IMR-90, MRC-5
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Ferrand et al. (2016) Screening of a kinase library reveals novel pro-senescence kinases and their common NF-κB-dependent transcriptional program. Aging (Albany NY) 7(11)986-1003 (PubMed)

HK3 Gene Information

HGNC symbol
HK3 
Aliases
 
Common name
hexokinase 3 
Entrez Id
3101
Description
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by its product glucose-6-phosphate. [provided by RefSeq, Apr 2009].

HK3 Ontologies

Gene Ontology
Process: GO:16310; phosphorylation
GO:6096; glycolytic process
GO:1678; cellular glucose homeostasis
GO:5975; carbohydrate metabolic process
GO:19318; hexose metabolic process
GO:46835; carbohydrate phosphorylation
GO:51156; glucose 6-phosphate metabolic process
GO:8152; metabolic process
GO:6002; fructose 6-phosphate metabolic process
GO:61621; canonical glycolysis
Cellular component: GO:5576; extracellular region
GO:5739; mitochondrion
GO:5829; cytosol
GO:34774; secretory granule lumen
GO:1904813; ficolin-1-rich granule lumen
Function: GO:166; nucleotide binding
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:4340; glucokinase activity
GO:4396; hexokinase activity
GO:5536; glucose binding
GO:16773; phosphotransferase activity, alcohol group as acceptor
GO:3824; catalytic activity
GO:5515; protein binding
GO:8865; fructokinase activity
And 2 more GO terms
Show all GO terms

Homologs of HK3 in Model Organisms

Caenorhabditis elegans
hxk-1
Drosophila melanogaster
Hex-A
Drosophila melanogaster
Hex-t1
Drosophila melanogaster
Hex-C
Drosophila melanogaster
Hex-t2
Mus musculus
Hk3
Rattus norvegicus
Hk3
Saccharomyces cerevisiae
HXK2
Saccharomyces cerevisiae
GLK1

In other databases

GenAge model organism genes
  • A homolog of this gene for Saccharomyces cerevisiae is present as HXK2
  • A homolog of this gene for Saccharomyces cerevisiae is present as GLK1
  • A homolog of this gene for Drosophila melanogaster is present as Hex-A
  • A homolog of this gene for Drosophila melanogaster is present as Hex-C
GenDR gene manipulations
  • A homolog of this gene for Drosophila melanogaster is present as Hex-C
  • A homolog of this gene for Saccharomyces cerevisiae is present as HXK2

External links

OMIM
142570
Ensembl
ENSG00000160883
Entrez Gene
3101
UniGene
411695
1000 Genomes
1000 Genomes
HPRD
GenAtlas
HK3
GeneCards
HK3