Cell Senescence Entries for HK3

Cell Types
Embryonic kidney, Lung fibroblast
Cell Lines
HEK293T, IMR-90, MRC-5
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Induces
Observations
A library of 200 constitutively activated kinases was screened in order to identify kinases whose constitutive expression decreased cell proliferation and induced expression of senescence markers; p16 and SASP components. A total of 33 kinases showed pro-senescence effects (particularly MAP3K7, PRKCD, and MATK); kinases with strong pro-senescence effects, induced expression of SASP-component genes (e.g. IL1A, IL1B, IL6 and IL8) through activation of an NF-kappaB-dependent transcriptional program. Inhibition of the NF-kappaB, p53, or Rb pathway proved insufficient to prevent kinase-triggered cell cycle arrest.
Primary Reference

    HK3 Gene Information

    HGNC symbol
    HK3 
    Aliases
    HXK3; HKIII 
    Common name
    hexokinase 3 
    Entrez Id
    3101
    Description
    Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by its product glucose-6-phosphate. [provided by RefSeq, Apr 2009]

    HK3 Ontologies

    Gene Ontology
    Process: GO:61621; canonical glycolysis
    GO:46835; carbohydrate phosphorylation
    GO:1678; cellular glucose homeostasis
    GO:51156; glucose 6-phosphate metabolic process
    GO:15758; glucose transport
    GO:6096; glycolytic process
    GO:43312; neutrophil degranulation
    Cellular component: GO:5829; cytosol
    GO:5576; extracellular region
    GO:1904813; ficolin-1-rich granule lumen
    GO:5739; mitochondrion
    GO:34774; secretory granule lumen
    Function: GO:5524; ATP binding
    GO:8865; fructokinase activity
    GO:4340; glucokinase activity
    GO:5536; glucose binding
    GO:4396; hexokinase activity
    GO:19158; mannokinase activity
    Show all GO terms

    Homologs of HK3 in Model Organisms

    Caenorhabditis elegans
    hxk-1
    Drosophila melanogaster
    Hex-A
    Drosophila melanogaster
    Hex-t1
    Drosophila melanogaster
    Hex-C
    Drosophila melanogaster
    Hex-t2
    Mus musculus
    Hk3
    Rattus norvegicus
    Hk3
    Saccharomyces cerevisiae
    HXK2
    Saccharomyces cerevisiae
    GLK1

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Saccharomyces cerevisiae is present as HXK2
    • A homolog of this gene for Saccharomyces cerevisiae is present as GLK1
    • A homolog of this gene for Drosophila melanogaster is present as Hex-A
    • A homolog of this gene for Drosophila melanogaster is present as Hex-C
    GenDR gene manipulations
    • A homolog of this gene for Drosophila melanogaster is present as Hex-C
    • A homolog of this gene for Saccharomyces cerevisiae is present as HXK2

    External links

    OMIM
    142570
    Ensembl
    ENSG00000160883
    Entrez Gene
    3101
    UniGene
    411695
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    HK3
    GeneCards
    HK3