Cell Senescence Entries for HIPK2
- Cell Types
- Lung cancer
- Cell Lines
- A549
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Induces
- Primary Reference
- Donninger et al. (2015) NORE1A is a Ras senescence effector that controls the apoptotic/senescent balance of p53 via HIPK2. J Cell Biol 208(6)777-89 (PubMed)
HIPK2 Gene Information
- HGNC symbol
- HIPK2
- Aliases
- Common name
- homeodomain interacting protein kinase 2
- Entrez Id
- 28996
- Description
- This gene encodes a conserved serine/threonine kinase that is a member of the homeodomain-interacting protein kinase family. The encoded protein interacts with homeodomain transcription factors and many other transcription factors such as p53, and can function as both a corepressor and a coactivator depending on the transcription factor and its subcellular localization. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].
HIPK2 Ontologies
- Gene Ontology
-
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:6915; apoptotic process
GO:18108; peptidyl-tyrosine phosphorylation
GO:6974; cellular response to DNA damage stimulus
GO:51726; regulation of cell cycle
GO:30218; erythrocyte differentiation
GO:45944; positive regulation of transcription by RNA polymerase II
GO:1654; eye development
GO:18105; peptidyl-serine phosphorylation
GO:18107; peptidyl-threonine phosphorylation
And 33 more GO terms Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:16605; PML body
GO:90575; RNA polymerase II transcription regulator complex
GO:16604; nuclear body
Function: GO:5515; protein binding
GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:3713; transcription coactivator activity
GO:3714; transcription corepressor activity
And 5 more GO terms
Homologs of HIPK2 in Model Organisms
- Caenorhabditis elegans
- hpk-1
- Danio rerio
- hipk2
- Drosophila melanogaster
- hipk
- Mus musculus
- Hipk2
- Rattus norvegicus
- Hipk2
- Saccharomyces cerevisiae
- YAK1
In other databases
- GenAge model organism genes
- GenDR gene expression
- A homolog of this gene for Mus musculus is present as Hipk2
External links
- OMIM
- 606868
- Ensembl
- ENSG00000064393
- Entrez Gene
- 28996
- UniGene
- 731417
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- HIPK2
- GeneCards
- HIPK2