Cell Senescence Entries for GRN

Cell Types
Cervical cancer
Cell Lines
HeLa, SiHa
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Zhang et al. (2016) Effect of progranulin (PGRN) on the proliferation and senescence of cervical cancer cells. Genet Mol Res 14(4)14331-8 (PubMed)

GRN Gene Information

HGNC symbol
GRN 
Aliases
CLN11; PCDGF; PGRN 
Common name
granulin precursor 
Entrez Id
2896
Description
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008].

GRN Ontologies

Gene Ontology
Process: GO:50821; protein stabilization
GO:43524; negative regulation of neuron apoptotic process
GO:7165; signal transduction
GO:30335; positive regulation of cell migration
GO:45766; positive regulation of angiogenesis
GO:10595; positive regulation of endothelial cell migration
GO:7040; lysosome organization
GO:7041; lysosomal transport
GO:50679; positive regulation of epithelial cell proliferation
GO:43525; positive regulation of neuron apoptotic process
GO:2282; microglial cell activation involved in immune response
And 13 more GO terms
Cellular component: GO:5576; extracellular region
GO:16020; membrane
GO:5794; Golgi apparatus
GO:5783; endoplasmic reticulum
GO:5886; plasma membrane
GO:5770; late endosome
GO:5765; lysosomal membrane
GO:5615; extracellular space
GO:5764; lysosome
GO:5802; trans-Golgi network
GO:5768; endosome
And 3 more GO terms
Function: GO:3723; RNA binding
GO:5515; protein binding
GO:5125; cytokine activity
GO:51087; chaperone binding
GO:8083; growth factor activity
Show all GO terms

Homologs of GRN in Model Organisms

Caenorhabditis elegans
pgrn-1
Danio rerio
grna
Danio rerio
grnb
Mus musculus
Grn
Rattus norvegicus
Grn

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Grn
GenAge human genes
  • This gene is present as GRN
GenAge microarray genes
  • This gene is present as GRN
CellAge gene expression
  • This gene is present as GRN

External links

OMIM
138945
Ensembl
ENSG00000030582
Entrez Gene
2896
UniGene
514220
1000 Genomes
1000 Genomes
HPRD
GenAtlas
GRN
GeneCards
GRN