Cell Senescence Entries for GRN
- Cell Types
- Cervical cancer
- Cell Lines
- HeLa, SiHa
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Unclear
- Senescence Effect
- Inhibits
- Primary Reference
- Zhang et al. (2016) Effect of progranulin (PGRN) on the proliferation and senescence of cervical cancer cells. Genet Mol Res 14(4)14331-8 (PubMed)
GRN Gene Information
- HGNC symbol
- GRN
- Aliases
- CLN11; PCDGF; PGRN
- Common name
- granulin precursor
- Entrez Id
- 2896
- Description
- Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008].
GRN Ontologies
- Gene Ontology
-
Process: GO:50821; protein stabilization
GO:43524; negative regulation of neuron apoptotic process
GO:7165; signal transduction
GO:30335; positive regulation of cell migration
GO:45766; positive regulation of angiogenesis
GO:10595; positive regulation of endothelial cell migration
GO:7040; lysosome organization
GO:7041; lysosomal transport
GO:50679; positive regulation of epithelial cell proliferation
GO:43525; positive regulation of neuron apoptotic process
GO:2282; microglial cell activation involved in immune response
And 13 more GO terms Cellular component: GO:5576; extracellular region
GO:16020; membrane
GO:5794; Golgi apparatus
GO:5783; endoplasmic reticulum
GO:5886; plasma membrane
GO:5770; late endosome
GO:5765; lysosomal membrane
GO:5615; extracellular space
GO:5764; lysosome
GO:5802; trans-Golgi network
GO:5768; endosome
And 3 more GO terms Function: GO:3723; RNA binding
GO:5515; protein binding
GO:5125; cytokine activity
GO:51087; chaperone binding
GO:8083; growth factor activity
Homologs of GRN in Model Organisms
In other databases
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Grn
- GenAge human genes
- This gene is present as GRN
- GenAge microarray genes
- This gene is present as GRN
- CellAge gene expression
- This gene is present as GRN
External links
- OMIM
- 138945
- Ensembl
- ENSG00000030582
- Entrez Gene
- 2896
- UniGene
- 514220
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- GRN
- GeneCards
- GRN