Cell Senescence Entries for GAPDH
- Cell Types
- Lung cancer
- Cell Lines
- A549
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Stress-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Phadke et al. (2011) Accelerated cellular senescence phenotype of GAPDH-depleted human lung carcinoma cells. Biochem Biophys Res Commun 411(2)409-15 (PubMed)
GAPDH Gene Information
- HGNC symbol
- GAPDH
- Aliases
- GAPD
- Common name
- glyceraldehyde-3-phosphate dehydrogenase
- Entrez Id
- 2597
- Description
- This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The encoded protein has additionally been identified to have uracil DNA glycosylase activity in the nucleus. Also, this protein contains a peptide that has antimicrobial activity against E. coli, P. aeruginosa, and C. albicans. Studies of a similar protein in mouse have assigned a variety of additional functions including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a transferrin receptor on the cell surface of macrophage. Many pseudogenes similar to this locus are present in the human genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014].
GAPDH Ontologies
- Gene Ontology
-
Process: GO:6915; apoptotic process
GO:6096; glycolytic process
GO:6417; regulation of translation
GO:17148; negative regulation of translation
GO:43123; positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:2376; immune system process
GO:45087; innate immune response
GO:6006; glucose metabolic process
GO:50821; protein stabilization
GO:1819; positive regulation of cytokine production
GO:71346; cellular response to interferon-gamma
And 11 more GO terms Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:43231; intracellular membrane-bounded organelle
GO:5829; cytosol
GO:5886; plasma membrane
GO:5856; cytoskeleton
GO:31965; nuclear membrane
GO:1990904; ribonucleoprotein complex
GO:48471; perinuclear region of cytoplasm
GO:31982; vesicle
And 5 more GO terms Function: GO:166; nucleotide binding
GO:16740; transferase activity
GO:16491; oxidoreductase activity
GO:50661; NADP binding
GO:51287; NAD binding
GO:5515; protein binding
GO:16620; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:8017; microtubule binding
GO:42802; identical protein binding
GO:4365; glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GO:97718; disordered domain specific binding
And 3 more GO terms
Homologs of GAPDH in Model Organisms
- Caenorhabditis elegans
- gpd-3
- Caenorhabditis elegans
- gpd-4
- Caenorhabditis elegans
- gpd-2
- Caenorhabditis elegans
- gpd-1
- Danio rerio
- gapdh
- Drosophila melanogaster
- CG9010
- Mus musculus
- Gm11214
- Mus musculus
- Gm10358
- Mus musculus
- Gapdh
- Mus musculus
- Gapdh
- Mus musculus
- Gm12117
- Mus musculus
- Gm15294
- Mus musculus
- Gm3839
- Saccharomyces cerevisiae
- TDH3
- Schizosaccharomyces pombe
- tdh1
In other databases
- GenAge model organism genes
External links
- OMIM
- 138400
- Ensembl
- ENSG00000111640
- Entrez Gene
- 2597
- UniGene
- 592355
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- GAPDH
- GeneCards
- GAPDH