Cell Senescence Entries for EGLN1
- Cell Types
- Endometrial cancer
- Cell Lines
- HHUA, HWCA, Ishikawa
- Cancer Cell?
- Yes
- Method
- Mutation, Overexpression
- Type of senescence
- Replicative
- Senescence Effect
- Induces
- Primary Reference
- Kato et al. (2006) Induction of human endometrial cancer cell senescence through modulation of HIF-1alpha activity by EGLN1. Int J Cancer 118(5)1144-53 (PubMed)
EGLN1 Gene Information
- HGNC symbol
- EGLN1
- Aliases
- C1orf12; HIFPH2; PHD2; SM-20; ZMYND6
- Common name
- egl-9 family hypoxia inducible factor 1
- Entrez Id
- 54583
- Description
- The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3). [provided by RefSeq, Nov 2009].
EGLN1 Ontologies
- Gene Ontology
-
Process: GO:18401; peptidyl-proline hydroxylation to 4-hydroxy-L-proline
GO:71456; cellular response to hypoxia
GO:45765; regulation of angiogenesis
GO:71731; response to nitric oxide
GO:1666; response to hypoxia
GO:51344; negative regulation of cyclic-nucleotide phosphodiesterase activity
GO:32364; oxygen homeostasis
GO:43433; negative regulation of DNA-binding transcription factor activity
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5829; cytosol
Function: GO:46872; metal ion binding
GO:16491; oxidoreductase activity
GO:5506; iron ion binding
GO:16705; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:31418; L-ascorbic acid binding
GO:51213; dioxygenase activity
GO:5515; protein binding
GO:8198; ferrous iron binding
GO:31543; peptidyl-proline dioxygenase activity
GO:31545; peptidyl-proline 4-dioxygenase activity
GO:19899; enzyme binding
And 2 more GO terms
Homologs of EGLN1 in Model Organisms
- Caenorhabditis elegans
- egl-9
- Danio rerio
- egln1a
- Drosophila melanogaster
- Hph
- Mus musculus
- Egln1
- Rattus norvegicus
- Egln1
- Rattus norvegicus
- AABR07004992.1
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as egl-9
- GenDR gene manipulations
- A homolog of this gene for Caenorhabditis elegans is present as egl-9
External links
- OMIM
- 606425
- Ensembl
- ENSG00000135766
- Entrez Gene
- 54583
- UniGene
- 444450
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- EGLN1
- GeneCards
- EGLN1