Cell Senescence Entries for AGO2
- Cell Types
- Embryonic kidney
- Cell Lines
- HEK293
- Cancer Cell?
- No
- Method
- Overexpression
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Yang et al. (2014) Dephosphorylation of tyrosine 393 in argonaute 2 by protein tyrosine phosphatase 1B regulates gene silencing in oncogenic RAS-induced senescence. Mol Cell 55(5)782-90 (PubMed)
AGO2 Gene Information
- HGNC symbol
- AGO2
- Aliases
- CASC7; EIF2C2; hAGO2; LINC00980; Q10
- Common name
- argonaute RISC catalytic component 2
- Entrez Id
- 27161
- Description
- This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].
AGO2 Ontologies
- Gene Ontology
-
Process: GO:90502; RNA phosphodiester bond hydrolysis, endonucleolytic
GO:6412; translation
GO:6355; regulation of transcription, DNA-templated
GO:6417; regulation of translation
GO:90305; nucleic acid phosphodiester bond hydrolysis
GO:31047; gene silencing by RNA
GO:6413; translational initiation
GO:60213; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:1900153; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45766; positive regulation of angiogenesis
And 20 more GO terms Cellular component: GO:5737; cytoplasm
GO:5634; nucleus
GO:16020; membrane
GO:5829; cytosol
GO:1990904; ribonucleoprotein complex
GO:36464; cytoplasmic ribonucleoprotein granule
GO:932; P-body
GO:16442; RISC complex
GO:5654; nucleoplasm
GO:5845; mRNA cap binding complex
GO:70578; RISC-loading complex
And 4 more GO terms Function: GO:35198; miRNA binding
GO:5515; protein binding
GO:3676; nucleic acid binding
GO:3723; RNA binding
GO:3743; translation initiation factor activity
GO:46872; metal ion binding
GO:16787; hydrolase activity
GO:4518; nuclease activity
GO:4519; endonuclease activity
GO:340; RNA 7-methylguanosine cap binding
GO:3727; single-stranded RNA binding
And 12 more GO terms
Homologs of AGO2 in Model Organisms
- Caenorhabditis elegans
- alg-2
- Caenorhabditis elegans
- alg-1
- Danio rerio
- ago2
- Drosophila melanogaster
- AGO1
- Mus musculus
- Ago2
- Rattus norvegicus
- Ago2
- Schizosaccharomyces pombe
- ago1
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as alg-2
External links
- OMIM
- 606229
- Ensembl
- ENSG00000123908
- Entrez Gene
- 27161
- UniGene
- 743313
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- AGO2
- GeneCards
- AGO2