Cell Senescence Entries for AGO2

Cell Types
Embryonic kidney
Cell Lines
HEK293
Cancer Cell?
No
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Yang et al. (2014) Dephosphorylation of tyrosine 393 in argonaute 2 by protein tyrosine phosphatase 1B regulates gene silencing in oncogenic RAS-induced senescence. Mol Cell 55(5)782-90 (PubMed)

AGO2 Gene Information

HGNC symbol
AGO2 
Aliases
CASC7; EIF2C2; hAGO2; LINC00980; Q10 
Common name
argonaute RISC catalytic component 2 
Entrez Id
27161
Description
This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].

AGO2 Ontologies

Gene Ontology
Process: GO:90502; RNA phosphodiester bond hydrolysis, endonucleolytic
GO:6412; translation
GO:6355; regulation of transcription, DNA-templated
GO:6417; regulation of translation
GO:90305; nucleic acid phosphodiester bond hydrolysis
GO:31047; gene silencing by RNA
GO:6413; translational initiation
GO:60213; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:1900153; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45766; positive regulation of angiogenesis
And 20 more GO terms
Cellular component: GO:5737; cytoplasm
GO:5634; nucleus
GO:16020; membrane
GO:5829; cytosol
GO:1990904; ribonucleoprotein complex
GO:36464; cytoplasmic ribonucleoprotein granule
GO:932; P-body
GO:16442; RISC complex
GO:5654; nucleoplasm
GO:5845; mRNA cap binding complex
GO:70578; RISC-loading complex
And 4 more GO terms
Function: GO:35198; miRNA binding
GO:5515; protein binding
GO:3676; nucleic acid binding
GO:3723; RNA binding
GO:3743; translation initiation factor activity
GO:46872; metal ion binding
GO:16787; hydrolase activity
GO:4518; nuclease activity
GO:4519; endonuclease activity
GO:340; RNA 7-methylguanosine cap binding
GO:3727; single-stranded RNA binding
And 12 more GO terms
Show all GO terms

Homologs of AGO2 in Model Organisms

Caenorhabditis elegans
alg-2
Caenorhabditis elegans
alg-1
Danio rerio
ago2
Drosophila melanogaster
AGO1
Mus musculus
Ago2
Rattus norvegicus
Ago2
Schizosaccharomyces pombe
ago1

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as alg-2

External links

OMIM
606229
Ensembl
ENSG00000123908
Entrez Gene
27161
UniGene
743313
1000 Genomes
1000 Genomes
HPRD
GenAtlas
AGO2
GeneCards
AGO2