The TGFBR1 gene and its putative association with human ageing

Cell Types

Lung cancer

Cell Lines

A549

Cancer Cell?

Yes

Method

Knockdown

Type of senescence

Unclear

Senescence Effect

Inhibits

Primary Reference

Gao et al. (2019) Lung cancer deficient in the tumor suppressor GATA4 is sensitive to TGFBR1 inhibition. Nat Commun 10(1)1665 (PubMed)

HGNC symbol

TGFBR1

Aliases

ACVRLK4; ALK-5; ALK5; ESS1; MSSE; TBR-i; TBRI

Common name

transforming growth factor beta receptor 1

Entrez Id

7046

Description

The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].

Gene Ontology

Process:

GO:6468; protein phosphorylation
GO:7178; transmembrane receptor protein serine/threonine kinase signaling pathway
GO:10628; positive regulation of gene expression
GO:16310; phosphorylation
GO:6915; apoptotic process
GO:30154; cell differentiation
GO:80090; regulation of primary metabolic process
GO:40008; regulation of growth
GO:18105; peptidyl-serine phosphorylation
GO:51726; regulation of cell cycle
GO:51171; regulation of nitrogen compound metabolic process
GO:7399; nervous system development
GO:60037; pharyngeal system development
GO:1938; positive regulation of endothelial cell proliferation
GO:7179; transforming growth factor beta receptor signaling pathway
GO:7507; heart development
GO:10468; regulation of gene expression
GO:10717; regulation of epithelial to mesenchymal transition
GO:32924; activin receptor signaling pathway
GO:35556; intracellular signal transduction
GO:42118; endothelial cell activation
GO:45893; positive regulation of transcription, DNA-templated
GO:48762; mesenchymal cell differentiation
GO:60317; cardiac epithelial to mesenchymal transition
GO:51897; positive regulation of protein kinase B signaling
GO:30335; positive regulation of cell migration
GO:71363; cellular response to growth factor stimulus
GO:8284; positive regulation of cell population proliferation
GO:30307; positive regulation of cell growth
GO:48844; artery morphogenesis
GO:51496; positive regulation of stress fiber assembly
GO:60978; angiogenesis involved in coronary vascular morphogenesis
GO:32331; negative regulation of chondrocyte differentiation
GO:42060; wound healing
GO:30199; collagen fibril organization
GO:60389; pathway-restricted SMAD protein phosphorylation
GO:60412; ventricular septum morphogenesis
GO:71560; cellular response to transforming growth factor beta stimulus
GO:18107; peptidyl-threonine phosphorylation
GO:10718; positive regulation of epithelial to mesenchymal transition
GO:1822; kidney development
GO:10862; positive regulation of pathway-restricted SMAD protein phosphorylation
GO:9952; anterior/posterior pattern specification
GO:1837; epithelial to mesenchymal transition
GO:43410; positive regulation of MAPK cascade
GO:2001235; positive regulation of apoptotic signaling pathway
GO:1501; skeletal system development
GO:2001237; negative regulation of extrinsic apoptotic signaling pathway
GO:1701; in utero embryonic development
GO:60391; positive regulation of SMAD protein signal transduction
GO:1905075; positive regulation of tight junction disassembly
GO:6355; regulation of transcription, DNA-templated
GO:48870; cell motility
GO:60021; roof of mouth development
GO:51272; positive regulation of cellular component movement
GO:60982; coronary artery morphogenesis
GO:3223; ventricular compact myocardium morphogenesis
GO:3222; ventricular trabecula myocardium morphogenesis
GO:1905007; positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
GO:48701; embryonic cranial skeleton morphogenesis
GO:31396; regulation of protein ubiquitination
GO:60043; regulation of cardiac muscle cell proliferation
GO:7165; signal transduction
GO:1525; angiogenesis
GO:1824; blastocyst development
GO:1937; negative regulation of endothelial cell proliferation
GO:2088; lens development in camera-type eye
GO:8354; germ cell migration
GO:8584; male gonad development
GO:9791; post-embryonic development
GO:43062; extracellular structure organization
GO:43065; positive regulation of apoptotic process
GO:43066; negative regulation of apoptotic process
GO:43393; regulation of protein binding
GO:43542; endothelial cell migration
GO:48538; thymus development
GO:48663; neuron fate commitment
GO:48705; skeletal system morphogenesis
GO:51491; positive regulation of filopodium assembly
GO:60017; parathyroid gland development
GO:70723; response to cholesterol
GO:1905223; epicardium morphogenesis
GO:10604; positive regulation of macromolecule metabolic process
GO:51173; positive regulation of nitrogen compound metabolic process
GO:51239; regulation of multicellular organismal process

Cellular component:

GO:16020; membrane
GO:16021; integral component of membrane
GO:5886; plasma membrane
GO:5634; nucleus
GO:5768; endosome
GO:30054; cell junction
GO:45121; membrane raft
GO:9986; cell surface
GO:5923; bicellular tight junction
GO:43235; receptor complex
GO:48179; activin receptor complex
GO:70021; transforming growth factor beta ligand-receptor complex

Function:

GO:166; nucleotide binding
GO:4674; protein serine/threonine kinase activity
GO:5524; ATP binding
GO:4675; transmembrane receptor protein serine/threonine kinase activity
GO:43167; ion binding
GO:5515; protein binding
GO:46872; metal ion binding
GO:4672; protein kinase activity
GO:16301; kinase activity
GO:16740; transferase activity
GO:5025; transforming growth factor beta receptor activity, type I
GO:50431; transforming growth factor beta binding
GO:46332; SMAD binding
GO:70411; I-SMAD binding
GO:48185; activin binding
GO:5114; type II transforming growth factor beta receptor binding
GO:19838; growth factor binding
GO:16361; activin receptor activity, type I
GO:5024; transforming growth factor beta-activated receptor activity
GO:5102; signaling receptor binding

Hide GO terms

Caenorhabditis elegans

sma-6

Danio rerio

tgfbr1a

Danio rerio

tgfbr1b

Drosophila melanogaster

babo

Mus musculus

Tgfbr1

Rattus norvegicus