Cell Senescence Entries for PRKD1
- Cell Types
- Lung fibroblast
- Cell Lines
- IMR-90
- Cancer Cell?
- No
- Method
- Knockdown, Overexpression
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Induces
- Primary Reference
- Wang et al. (2014) Protein kinase D1 is essential for Ras-induced senescence and tumor suppression by regulating senescence-associated inflammation. Proc Natl Acad Sci U S A 111(21)7683-8 (PubMed)
PRKD1 Gene Information
- HGNC symbol
- PRKD1
- Aliases
- PKC-mu; PKCM; PKD; PRKCM
- Common name
- protein kinase D1
- Entrez Id
- 5587
- Description
- The protein encoded by this gene is a serine/threonine protein kinase involved in many cellular processes, including Golgi body membrane integrity and transport, cell migration and differentiation, MAPK8/JNK1 and Ras pathway signaling, MAPK1/3 (ERK1/2) pathway signaling, cell survival, and regulation of cell shape and adhesion. [provided by RefSeq, Jan 2017].
PRKD1 Ontologies
- Gene Ontology
-
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:6915; apoptotic process
GO:43123; positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:30154; cell differentiation
GO:2376; immune system process
GO:45087; innate immune response
GO:7399; nervous system development
GO:18105; peptidyl-serine phosphorylation
GO:6954; inflammatory response
GO:1525; angiogenesis
GO:46777; protein autophosphorylation
GO:7265; Ras protein signal transduction
GO:7030; Golgi organization
GO:31647; regulation of protein stability
GO:34599; cellular response to oxidative stress
GO:33138; positive regulation of peptidyl-serine phosphorylation
GO:45944; positive regulation of transcription by RNA polymerase II
GO:1938; positive regulation of endothelial cell proliferation
GO:7165; signal transduction
GO:51092; positive regulation of NF-kappaB transcription factor activity
GO:45766; positive regulation of angiogenesis
GO:30148; sphingolipid biosynthetic process
GO:10595; positive regulation of endothelial cell migration
GO:35924; cellular response to vascular endothelial growth factor stimulus
GO:18107; peptidyl-threonine phosphorylation
GO:7229; integrin-mediated signaling pathway
GO:48010; vascular endothelial growth factor receptor signaling pathway
GO:43536; positive regulation of blood vessel endothelial cell migration
GO:10976; positive regulation of neuron projection development
GO:60548; negative regulation of cell death
GO:48193; Golgi vesicle transport
GO:35556; intracellular signal transduction
GO:89700; protein kinase D signaling
GO:45669; positive regulation of osteoblast differentiation
GO:38033; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
GO:2001028; positive regulation of endothelial cell chemotaxis
GO:32793; positive regulation of CREB transcription factor activity
GO:1901727; positive regulation of histone deacetylase activity
GO:45806; negative regulation of endocytosis
GO:10837; regulation of keratinocyte proliferation
GO:10508; positive regulation of autophagy
GO:71447; cellular response to hydroperoxide
GO:34198; cellular response to amino acid starvation
GO:42307; positive regulation of protein import into nucleus
GO:43552; positive regulation of phosphatidylinositol 3-kinase activity
GO:50829; defense response to Gram-negative bacterium
GO:51279; regulation of release of sequestered calcium ion into cytosol
GO:2001044; regulation of integrin-mediated signaling pathway
Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:5794; Golgi apparatus
GO:5829; cytosol
GO:5886; plasma membrane
GO:5802; trans-Golgi network
GO:421; autophagosome membrane
GO:5634; nucleus
GO:5911; cell-cell junction
GO:5938; cell cortex
Hide GO termsFunction: GO:46872; metal ion binding
GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:5515; protein binding
GO:4697; protein kinase C activity
GO:4698; calcium-dependent protein kinase C activity
GO:42802; identical protein binding
Homologs of PRKD1 in Model Organisms
- Caenorhabditis elegans
- dkf-1
- Caenorhabditis elegans
- dkf-2
- Danio rerio
- prkd1
- Drosophila melanogaster
- PKD
- Mus musculus
- Prkd1
- Rattus norvegicus
- Prkd1
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as dkf-2
External links
- OMIM
- 605435
- Ensembl
- ENSG00000184304
- Entrez Gene
- 5587
- UniGene
- 508999
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- PRKD1
- GeneCards
- PRKD1