The PINK1 gene and its putative association with human ageing

Cell Types

Nucleus pulposus

Cell Lines

Primary cell

Cancer Cell?

No

Method

Knockdown

Type of senescence

Stress-induced

Senescence Effect

Inhibits

Primary Reference

Wang et al. (2019) PINK1 protects against oxidative stress induced senescence of human nucleus pulposus cells via regulating mitophagy. Biochem Biophys Res Commun 504(2)406-414 (PubMed)

HGNC symbol

PINK1

Aliases

BRPK; PARK6

Common name

PTEN induced kinase 1

Entrez Id

65018

Description

This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease. [provided by RefSeq, Jul 2008].

Gene Ontology

Process:

GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:16567; protein ubiquitination
GO:6914; autophagy
GO:35556; intracellular signal transduction
GO:50821; protein stabilization
GO:422; autophagy of mitochondrion
GO:42981; regulation of apoptotic process
GO:31396; regulation of protein ubiquitination
GO:1903146; regulation of autophagy of mitochondrion
GO:1903214; regulation of protein targeting to mitochondrion
GO:90200; positive regulation of release of cytochrome c from mitochondria
GO:51897; positive regulation of protein kinase B signaling
GO:7005; mitochondrion organization
GO:2001243; negative regulation of intrinsic apoptotic signaling pathway
GO:43123; positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:1903955; positive regulation of protein targeting to mitochondrion
GO:18105; peptidyl-serine phosphorylation
GO:423; mitophagy
GO:30097; hemopoiesis
GO:34599; cellular response to oxidative stress
GO:6511; ubiquitin-dependent protein catabolic process
GO:6979; response to oxidative stress
GO:10629; negative regulation of gene expression
GO:10821; regulation of mitochondrion organization
GO:43524; negative regulation of neuron apoptotic process
GO:46329; negative regulation of JNK cascade
GO:97237; cellular response to toxic substance
GO:98779; positive regulation of mitophagy in response to mitochondrial depolarization
GO:99074; mitochondrion to lysosome transport
GO:1900407; regulation of cellular response to oxidative stress
GO:1902803; regulation of synaptic vesicle transport
GO:1903202; negative regulation of oxidative stress-induced cell death
GO:2000378; negative regulation of reactive oxygen species metabolic process
GO:36289; peptidyl-serine autophosphorylation
GO:31398; positive regulation of protein ubiquitination
GO:43254; regulation of protein-containing complex assembly
GO:32148; activation of protein kinase B activity
GO:33138; positive regulation of peptidyl-serine phosphorylation
GO:90258; negative regulation of mitochondrial fission
GO:72655; establishment of protein localization to mitochondrion
GO:1903204; negative regulation of oxidative stress-induced neuron death
GO:72656; maintenance of protein location in mitochondrion
GO:16242; negative regulation of macroautophagy
GO:51881; regulation of mitochondrial membrane potential
GO:71456; cellular response to hypoxia
GO:16239; positive regulation of macroautophagy
GO:1901525; negative regulation of mitophagy
GO:10952; positive regulation of peptidase activity
GO:2001171; positive regulation of ATP biosynthetic process
GO:51443; positive regulation of ubiquitin-protein transferase activity
GO:1903751; negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
GO:1902902; negative regulation of autophagosome assembly
GO:90141; positive regulation of mitochondrial fission
GO:1902958; positive regulation of mitochondrial electron transport, NADH to ubiquinone
GO:1903384; negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway
GO:1934; positive regulation of protein phosphorylation
GO:2082; regulation of oxidative phosphorylation
GO:2931; response to ischemia
GO:10310; regulation of hydrogen peroxide metabolic process
GO:22904; respiratory electron transport chain
GO:32226; positive regulation of synaptic transmission, dopaminergic
GO:33603; positive regulation of dopamine secretion
GO:33605; positive regulation of catecholamine secretion
GO:35307; positive regulation of protein dephosphorylation
GO:38203; TORC2 signaling
GO:43066; negative regulation of apoptotic process
GO:43523; regulation of neuron apoptotic process
GO:45727; positive regulation of translation
GO:51091; positive regulation of DNA-binding transcription factor activity
GO:61136; regulation of proteasomal protein catabolic process
GO:1901215; negative regulation of neuron death
GO:1901727; positive regulation of histone deacetylase activity
GO:1903298; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
GO:1903852; positive regulation of cristae formation
GO:1904544; positive regulation of free ubiquitin chain polymerization
GO:1904783; positive regulation of NMDA glutamate receptor activity
GO:1904881; cellular response to hydrogen sulfide
GO:1904925; positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization
GO:2000377; regulation of reactive oxygen species metabolic process

Cellular component:

GO:5737; cytoplasm
GO:16020; membrane
GO:16021; integral component of membrane
GO:5783; endoplasmic reticulum
GO:5739; mitochondrion
GO:5743; mitochondrial inner membrane
GO:5741; mitochondrial outer membrane
GO:5829; cytosol
GO:5634; nucleus
GO:48471; perinuclear region of cytoplasm
GO:785; chromatin
GO:5856; cytoskeleton
GO:5758; mitochondrial intermembrane space
GO:97413; Lewy body
GO:44297; cell body
GO:30424; axon
GO:30426; growth cone
GO:31307; integral component of mitochondrial outer membrane
GO:97449; astrocyte projection

Function:

GO:46872; metal ion binding
GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:31625; ubiquitin protein ligase binding
GO:5515; protein binding
GO:287; magnesium ion binding
GO:44877; protein-containing complex binding
GO:2020; protease binding
GO:55131; C3HC4-type RING finger domain binding
GO:10857; calcium-dependent protein kinase activity
GO:16504; peptidase activator activity
GO:43422; protein kinase B binding
GO:1904841; TORC2 complex binding

Hide GO terms

Caenorhabditis elegans

pink-1

Danio rerio

pink1

Drosophila melanogaster

Pink1

Mus musculus

Pink1

Rattus norvegicus

Pink1

GenAge model organism genes