Cell Senescence Entries for PAK2
- Cell Types
- Lung fibroblast
- Cell Lines
- IMR-90
- Cancer Cell?
- No
- Method
- Knockdown, Overexpression
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Induces
- Primary Reference
- Lee et al. (2020) Pak2 kinase promotes cellular senescence and organismal aging. Proc Natl Acad Sci U S A 116(27)13311-13319 (PubMed)
PAK2 Gene Information
- HGNC symbol
- PAK2
- Aliases
- PAK65; PAKgamma
- Common name
- p21 (RAC1) activated kinase 2
- Entrez Id
- 5062
- Description
- The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. [provided by RefSeq, Jul 2008].
PAK2 Ontologies
- Gene Ontology
-
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:43066; negative regulation of apoptotic process
GO:6915; apoptotic process
GO:42981; regulation of apoptotic process
GO:8152; metabolic process
GO:40008; regulation of growth
GO:61098; positive regulation of protein tyrosine kinase activity
GO:35556; intracellular signal transduction
GO:50731; positive regulation of peptidyl-tyrosine phosphorylation
GO:7165; signal transduction
GO:2223; stimulatory C-type lectin receptor signaling pathway
GO:18105; peptidyl-serine phosphorylation
GO:2001238; positive regulation of extrinsic apoptotic signaling pathway
GO:43408; regulation of MAPK cascade
GO:50770; regulation of axonogenesis
GO:70830; bicellular tight junction assembly
GO:48010; vascular endothelial growth factor receptor signaling pathway
GO:150105; protein localization to cell-cell junction
GO:6469; negative regulation of protein kinase activity
GO:46777; protein autophosphorylation
GO:34333; adherens junction assembly
GO:51493; regulation of cytoskeleton organization
GO:51497; negative regulation of stress fiber assembly
GO:3300; cardiac muscle hypertrophy
GO:60996; dendritic spine development
GO:71407; cellular response to organic cyclic compound
GO:71560; cellular response to transforming growth factor beta stimulus
GO:2001271; negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
Cellular component: GO:5737; cytoplasm
GO:5634; nucleus
GO:16020; membrane
GO:48471; perinuclear region of cytoplasm
GO:5886; plasma membrane
GO:5829; cytosol
GO:5911; cell-cell junction
GO:14069; postsynaptic density
GO:30141; secretory granule
GO:98978; glutamatergic synapse
Hide GO termsFunction: GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:3824; catalytic activity
GO:5515; protein binding
GO:42802; identical protein binding
GO:45296; cadherin binding
GO:19901; protein kinase binding
GO:31267; small GTPase binding
GO:30296; protein tyrosine kinase activator activity
Homologs of PAK2 in Model Organisms
- Caenorhabditis elegans
- pak-1
- Danio rerio
- pak2b
- Danio rerio
- pak2a
- Drosophila melanogaster
- Pak
- Mus musculus
- Pak2
- Rattus norvegicus
- Pak2
- Rattus norvegicus
- LOC100910732
- Saccharomyces cerevisiae
- STE20
- Schizosaccharomyces pombe
- shk1
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as pak-1
External links
- OMIM
- 605022
- Ensembl
- ENSG00000180370
- Entrez Gene
- 5062
- UniGene
- 518530
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- PAK2
- GeneCards
- PAK2