Cell Senescence Entries for LATS1
- Cell Types
- Embryonic kidney, Retinal pigment epithelial
- Cell Lines
- HEK293T, HTERT-RPE1
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Unclear
- Senescence Effect
- Inhibits
- Primary Reference
- Lahtela et al. (2013) A high-content cellular senescence screen identifies candidate tumor suppressors, including EPHA3. Cell Cycle 12(4)625-34 (PubMed)
LATS1 Gene Information
- HGNC symbol
- LATS1
- Aliases
- WARTS
- Common name
- large tumor suppressor kinase 1
- Entrez Id
- 9113
- Description
- The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. [provided by RefSeq, Apr 2017].
LATS1 Ontologies
- Gene Ontology
-
Process: GO:6468; protein phosphorylation
GO:7049; cell cycle
GO:16310; phosphorylation
GO:35329; hippo signaling
GO:51301; cell division
GO:278; mitotic cell cycle
GO:35556; intracellular signal transduction
GO:9755; hormone-mediated signaling pathway
GO:18105; peptidyl-serine phosphorylation
GO:33138; positive regulation of peptidyl-serine phosphorylation
GO:43065; positive regulation of apoptotic process
GO:45736; negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:60644; mammary gland epithelial cell differentiation
GO:90090; negative regulation of canonical Wnt signaling pathway
GO:86; G2/M transition of mitotic cell cycle
GO:30833; regulation of actin filament polymerization
GO:33146; regulation of intracellular estrogen receptor signaling pathway
GO:82; G1/S transition of mitotic cell cycle
GO:819; sister chromatid segregation
GO:1827; inner cell mass cell fate commitment
GO:1828; inner cell mass cellular morphogenesis
GO:17015; regulation of transforming growth factor beta receptor signaling pathway
GO:30216; keratinocyte differentiation
GO:34613; cellular protein localization
GO:43254; regulation of protein-containing complex assembly
GO:46620; regulation of organ growth
GO:51220; cytoplasmic sequestering of protein
GO:1900181; negative regulation of protein localization to nucleus
GO:2000058; regulation of ubiquitin-dependent protein catabolic process
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5856; cytoskeleton
GO:5815; microtubule organizing center
GO:5819; spindle
GO:30496; midbody
GO:922; spindle pole
GO:5829; cytosol
Hide GO termsFunction: GO:5515; protein binding
GO:46872; metal ion binding
GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:287; magnesium ion binding
GO:19901; protein kinase binding
GO:30331; estrogen receptor binding
Homologs of LATS1 in Model Organisms
- Caenorhabditis elegans
- wts-1
- Danio rerio
- lats1
- Drosophila melanogaster
- wts
- Mus musculus
- Lats1
- Rattus norvegicus
- Lats1
- Saccharomyces cerevisiae
- CBK1
- Schizosaccharomyces pombe
- mkh1
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as wts-1
External links
- OMIM
- 603473
- Ensembl
- ENSG00000131023
- Entrez Gene
- 9113
- UniGene
- 549084
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- LATS1
- GeneCards
- LATS1