The IL6 gene and its putative association with human ageing

Cell Types

Fibroblast

Cell Lines

TIG-3

Cancer Cell?

No

Method

Knockdown

Type of senescence

Oncogene-induced, Stress-induced

Senescence Effect

Induces

Primary Reference

Kuilman et al. (2008) Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network. Cell 133(6)1019-31 (PubMed)

HGNC symbol

IL6

Aliases

BSF2; HGF; HSF; IFNB2; IL-6

Common name

interleukin 6

Entrez Id

3569

Description

This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Elevated levels of the encoded protein have been found in virus infections, including COVID-19 (disease caused by SARS-CoV-2). [provided by RefSeq, Aug 2020].

Gene Ontology

Process:

GO:10628; positive regulation of gene expression
GO:43066; negative regulation of apoptotic process
GO:7165; signal transduction
GO:45893; positive regulation of transcription, DNA-templated
GO:6955; immune response
GO:43065; positive regulation of apoptotic process
GO:6953; acute-phase response
GO:46427; positive regulation of receptor signaling pathway via JAK-STAT
GO:98586; cellular response to virus
GO:8284; positive regulation of cell population proliferation
GO:72540; T-helper 17 cell lineage commitment
GO:45944; positive regulation of transcription by RNA polymerase II
GO:32682; negative regulation of chemokine production
GO:32722; positive regulation of chemokine production
GO:32755; positive regulation of interleukin-6 production
GO:32757; positive regulation of interleukin-8 production
GO:32760; positive regulation of tumor necrosis factor production
GO:50829; defense response to Gram-negative bacterium
GO:1900017; positive regulation of cytokine production involved in inflammatory response
GO:45669; positive regulation of osteoblast differentiation
GO:50796; regulation of insulin secretion
GO:51091; positive regulation of DNA-binding transcription factor activity
GO:35633; maintenance of blood-brain barrier
GO:45727; positive regulation of translation
GO:6954; inflammatory response
GO:45599; negative regulation of fat cell differentiation
GO:8285; negative regulation of cell population proliferation
GO:2548; monocyte chemotaxis
GO:19221; cytokine-mediated signaling pathway
GO:51607; defense response to virus
GO:42593; glucose homeostasis
GO:70092; regulation of glucagon secretion
GO:32731; positive regulation of interleukin-1 beta production
GO:45765; regulation of angiogenesis
GO:1901731; positive regulation of platelet aggregation
GO:42531; positive regulation of tyrosine phosphorylation of STAT protein
GO:1904996; positive regulation of leukocyte adhesion to vascular endothelial cell
GO:150078; positive regulation of neuroinflammatory response
GO:30168; platelet activation
GO:43410; positive regulation of MAPK cascade
GO:48661; positive regulation of smooth muscle cell proliferation
GO:14823; response to activity
GO:10573; vascular endothelial growth factor production
GO:10888; negative regulation of lipid storage
GO:50768; negative regulation of neurogenesis
GO:51384; response to glucocorticoid
GO:60252; positive regulation of glial cell proliferation
GO:42102; positive regulation of T cell proliferation
GO:50830; defense response to Gram-positive bacterium
GO:2639; positive regulation of immunoglobulin production
GO:71222; cellular response to lipopolysaccharide
GO:2446; neutrophil mediated immunity
GO:32733; positive regulation of interleukin-10 production
GO:1904894; positive regulation of receptor signaling pathway via STAT
GO:2000635; negative regulation of primary miRNA processing
GO:33138; positive regulation of peptidyl-serine phosphorylation
GO:50731; positive regulation of peptidyl-tyrosine phosphorylation
GO:1903800; positive regulation of production of miRNAs involved in gene silencing by miRNA
GO:1781; neutrophil apoptotic process
GO:2314; germinal center B cell differentiation
GO:2384; hepatic immune response
GO:2675; positive regulation of acute inflammatory response
GO:2690; positive regulation of leukocyte chemotaxis
GO:6959; humoral immune response
GO:10574; regulation of vascular endothelial growth factor production
GO:10575; positive regulation of vascular endothelial growth factor production
GO:10718; positive regulation of epithelial to mesenchymal transition
GO:31018; endocrine pancreas development
GO:31175; neuron projection development
GO:32494; response to peptidoglycan
GO:32740; positive regulation of interleukin-17 production
GO:32745; positive regulation of interleukin-21 production
GO:32966; negative regulation of collagen biosynthetic process
GO:45779; negative regulation of bone resorption
GO:50871; positive regulation of B cell activation
GO:61470; T follicular helper cell differentiation
GO:61888; regulation of astrocyte activation
GO:70050; neuron cellular homeostasis
GO:70091; glucagon secretion
GO:70102; interleukin-6-mediated signaling pathway
GO:70301; cellular response to hydrogen peroxide
GO:72574; hepatocyte proliferation
GO:90091; positive regulation of extracellular matrix disassembly
GO:97421; liver regeneration
GO:150077; regulation of neuroinflammatory response
GO:1902512; positive regulation of apoptotic DNA fragmentation
GO:1903978; regulation of microglial cell activation
GO:2000553; positive regulation of T-helper 2 cell cytokine production
GO:2000660; negative regulation of interleukin-1-mediated signaling pathway
GO:2000676; positive regulation of type B pancreatic cell apoptotic process

Cellular component:

GO:5615; extracellular space
GO:5576; extracellular region
GO:5788; endoplasmic reticulum lumen
GO:5896; interleukin-6 receptor complex

Function:

GO:5515; protein binding
GO:5125; cytokine activity
GO:8083; growth factor activity
GO:5102; signaling receptor binding
GO:5138; interleukin-6 receptor binding

Hide GO terms

Mus musculus

Il6

Rattus norvegicus

Il6

GenAge human genes