The GSK3A gene and its putative association with human ageing

Cell Senescence Entries for GSK3A

Cell Types: Cervical cancer
Cell Lines: HeLa
Cancer Cell?: Yes
Method: Knockdown
Type of senescence: Unclear
Senescence Effect: Inhibits
Primary Reference: Kim et al. (2014) Glycogen Synthase Kinase 3 Inactivation Induces Cell Senescence through Sterol Regulatory Element Binding Protein 1-Mediated Lipogenesis in Chang Cells. Endocrinol Metab (Seoul) 28(4)297-308 (PubMed)

GSK3A Gene Information

HGNC symbol: GSK3A
Aliases
Common name: glycogen synthase kinase 3 alpha
Entrez Id: 2931
Description: This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease. [provided by RefSeq, Oct 2011].

GSK3A Ontologies

Gene Ontology

Process:

GO:6468; protein phosphorylation
GO:5975; carbohydrate metabolic process
GO:9968; negative regulation of signal transduction
GO:5977; glycogen metabolic process
GO:16055; Wnt signaling pathway
GO:51093; negative regulation of developmental process
GO:51128; regulation of cellular component organization
GO:16310; phosphorylation
GO:7399; nervous system development
GO:43161; proteasome-mediated ubiquitin-dependent protein catabolic process
GO:90090; negative regulation of canonical Wnt signaling pathway
GO:7165; signal transduction
GO:10508; positive regulation of autophagy
GO:8286; insulin receptor signaling pathway
GO:10975; regulation of neuron projection development
GO:32007; negative regulation of TOR signaling
GO:97192; extrinsic apoptotic signaling pathway in absence of ligand
GO:1903146; regulation of autophagy of mitochondrion
GO:10628; positive regulation of gene expression
GO:45732; positive regulation of protein catabolic process
GO:1903955; positive regulation of protein targeting to mitochondrion
GO:32869; cellular response to insulin stimulus
GO:18107; peptidyl-threonine phosphorylation
GO:1902004; positive regulation of amyloid-beta formation
GO:3073; regulation of systemic arterial blood pressure
GO:2000467; positive regulation of glycogen (starch) synthase activity
GO:46627; negative regulation of insulin receptor signaling pathway
GO:36016; cellular response to interleukin-3
GO:19082; viral protein processing
GO:60079; excitatory postsynaptic potential
GO:3214; cardiac left ventricle morphogenesis
GO:106071; positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:46325; negative regulation of glucose import
GO:45823; positive regulation of heart contraction
GO:32436; positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:7212; dopamine receptor signaling pathway
GO:10905; negative regulation of UDP-glucose catabolic process
GO:31398; positive regulation of protein ubiquitination
GO:45719; negative regulation of glycogen biosynthetic process
GO:61052; negative regulation of cell growth involved in cardiac muscle cell development
GO:71879; positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway
GO:97191; extrinsic apoptotic signaling pathway
GO:1901030; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1904227; negative regulation of glycogen synthase activity, transferring glucose-1-phosphate
GO:2000077; negative regulation of type B pancreatic cell development
GO:2000466; negative regulation of glycogen (starch) synthase activity

Cellular component:

GO:5739; mitochondrion
GO:5634; nucleus
GO:5737; cytoplasm
GO:98794; postsynapse
GO:5829; cytosol
GO:30424; axon
GO:43025; neuronal cell body
GO:30877; beta-catenin destruction complex
GO:1990635; proximal dendrite
GO:97440; apical dendrite

Function:

GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:5524; ATP binding
GO:16740; transferase activity
GO:50321; tau-protein kinase activity
GO:5515; protein binding
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:16301; kinase activity
GO:106310; protein serine kinase activity
GO:5102; signaling receptor binding
GO:48156; tau protein binding
GO:34236; protein kinase A catalytic subunit binding

Hide GO terms

Homologs of GSK3A in Model Organisms

Caenorhabditis elegans: gsk-3
Danio rerio: gsk3aa
Danio rerio: gsk3ab
Drosophila melanogaster: sgg
Saccharomyces cerevisiae: MRK1
Saccharomyces cerevisiae: RIM11
Schizosaccharomyces pombe: gsk3

In other databases

GenAge model organism genes

A homolog of this gene for Saccharomyces cerevisiae is present as RIM11
A homolog of this gene for Schizosaccharomyces pombe is present as gsk3

GenAge human genes

This gene is present as GSK3A

Cell Senescence Entries for GSK3A

GSK3A Gene Information

GSK3A Ontologies

Homologs of GSK3A in Model Organisms

In other databases

External links