Cell Senescence Entries for EIF4E
- Cell Types
- Lung cancer
- Cell Lines
- A549
- Cancer Cell?
- Yes
- Method
- Overexpression
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Unclear
- Primary Reference
- Chao et al. (2011) Insights into 4E-BP1 and p53 mediated regulation of accelerated cell senescence. Oncotarget 2(1-2)89-98 (PubMed)
EIF4E Gene Information
- HGNC symbol
- EIF4E
- Aliases
- EIF4E1; EIF4EL1; EIF4F
- Common name
- eukaryotic translation initiation factor 4E
- Entrez Id
- 1977
- Description
- The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].
EIF4E Ontologies
- Gene Ontology
-
Process: GO:6412; translation
GO:6413; translational initiation
GO:6417; regulation of translation
GO:82; G1/S transition of mitotic cell cycle
GO:45931; positive regulation of mitotic cell cycle
GO:1662; behavioral fear response
GO:17148; negative regulation of translation
GO:19827; stem cell population maintenance
GO:45665; negative regulation of neuron differentiation
GO:71549; cellular response to dexamethasone stimulus
GO:99578; regulation of translation at postsynapse, modulating synaptic transmission
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5829; cytosol
GO:36464; cytoplasmic ribonucleoprotein granule
GO:48471; perinuclear region of cytoplasm
GO:932; P-body
GO:10494; cytoplasmic stress granule
GO:98794; postsynapse
GO:70062; extracellular exosome
GO:5845; mRNA cap binding complex
GO:16281; eukaryotic translation initiation factor 4F complex
GO:16442; RISC complex
GO:33391; chromatoid body
GO:98978; glutamatergic synapse
Hide GO termsFunction: GO:3723; RNA binding
GO:3743; translation initiation factor activity
GO:5515; protein binding
GO:340; RNA 7-methylguanosine cap binding
GO:19899; enzyme binding
GO:31370; eukaryotic initiation factor 4G binding
GO:140297; DNA-binding transcription factor binding
GO:339; RNA cap binding
GO:45182; translation regulator activity
Homologs of EIF4E in Model Organisms
- Caenorhabditis elegans
- ife-1
- Caenorhabditis elegans
- ife-3
- Caenorhabditis elegans
- ife-2
- Caenorhabditis elegans
- ife-5
- Danio rerio
- eif4eb
- Danio rerio
- eif4ea
- Drosophila melanogaster
- eIF4E-5
- Drosophila melanogaster
- eIF4E-4
- Drosophila melanogaster
- eIF4E-7
- Drosophila melanogaster
- eIF-4E
- Drosophila melanogaster
- eIF4E-3
- Drosophila melanogaster
- eIF4E-6
- Mus musculus
- Eif4e
- Rattus norvegicus
- Eif4e
- Saccharomyces cerevisiae
- CDC33
In other databases
- GenAge model organism genes
- LongevityMap
- This gene is present as EIF4E
External links
- OMIM
- 133440
- Ensembl
- ENSG00000151247
- Entrez Gene
- 1977
- UniGene
- 249718
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- EIF4E
- GeneCards
- EIF4E