Cell Senescence Entries for CASP2
- Cell Types
- Mammary epithelial
- Cell Lines
- Primary cell
- Cancer Cell?
- No
- Method
- Knockdown
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Induces
- Primary Reference
- Gitenay et al. (2015) Caspase-2 regulates oncogene-induced senescence. Oncotarget 5(14)5845-7 (PubMed)
CASP2 Gene Information
- HGNC symbol
- CASP2
- Aliases
- ICH1; MGC2181; NEDD2; PPP1R57
- Common name
- caspase 2
- Entrez Id
- 835
- Description
- This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011].
CASP2 Ontologies
- Gene Ontology
-
Process: GO:42981; regulation of apoptotic process
GO:6508; proteolysis
GO:97194; execution phase of apoptosis
GO:43066; negative regulation of apoptotic process
GO:6915; apoptotic process
GO:43065; positive regulation of apoptotic process
GO:1554; luteolysis
GO:3407; neural retina development
GO:7420; brain development
GO:7568; aging
GO:35234; ectopic germ cell programmed cell death
GO:43525; positive regulation of neuron apoptotic process
GO:97190; apoptotic signaling pathway
GO:97192; extrinsic apoptotic signaling pathway in absence of ligand
GO:2001235; positive regulation of apoptotic signaling pathway
GO:71260; cellular response to mechanical stimulus
GO:8630; intrinsic apoptotic signaling pathway in response to DNA damage
GO:6919; activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:16485; protein processing
GO:6977; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:6974; cellular response to DNA damage stimulus
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5739; mitochondrion
GO:16020; membrane
GO:5829; cytosol
GO:5730; nucleolus
GO:1905369; endopeptidase complex
Hide GO termsFunction: GO:4197; cysteine-type endopeptidase activity
GO:97200; cysteine-type endopeptidase activity involved in execution phase of apoptosis
GO:8233; peptidase activity
GO:8234; cysteine-type peptidase activity
GO:16787; hydrolase activity
GO:5515; protein binding
GO:19899; enzyme binding
GO:42802; identical protein binding
GO:97153; cysteine-type endopeptidase activity involved in apoptotic process
GO:19904; protein domain specific binding
GO:97199; cysteine-type endopeptidase activity involved in apoptotic signaling pathway
Homologs of CASP2 in Model Organisms
- Caenorhabditis elegans
- csp-2
- Caenorhabditis elegans
- ced-3
- Caenorhabditis elegans
- csp-1
- Caenorhabditis elegans
- csp-3
- Danio rerio
- casp2
- Drosophila melanogaster
- Dronc
- Mus musculus
- Casp2
- Rattus norvegicus
- Casp2
In other databases
- GenAge model organism genes
External links
- OMIM
- 600639
- Ensembl
- ENSG00000106144
- Entrez Gene
- 835
- UniGene
- 368982
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- CASP2
- GeneCards
- CASP2