Cell Senescence Entries for VDR
- Cell Types
- Foreskin fibroblast
- Cell Lines
- BJ
- Cancer Cell?
- No
- Method
- Knockdown
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Graziano et al. (2017) Vitamin D/vitamin D receptor axis regulates DNA repair during oncogene-induced senescence. Oncogene 35(41)5362-5376 (PubMed)
VDR Gene Information
- HGNC symbol
- VDR
- Aliases
- NR1I1; PPP1R163
- Common name
- vitamin D receptor
- Entrez Id
- 7421
- Description
- This gene encodes vitamin D3 receptor, which is a member of the nuclear hormone receptor superfamily of ligand-inducible transcription factors. This receptor also functions as a receptor for the secondary bile acid, lithocholic acid. Downstream targets of vitamin D3 receptor are principally involved in mineral metabolism, though this receptor regulates a variety of other metabolic pathways, such as those involved in immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Jun 2018].
VDR Ontologies
- Gene Ontology
-
Process: GO:6355; regulation of transcription, DNA-templated
GO:45944; positive regulation of transcription by RNA polymerase II
GO:30522; intracellular receptor signaling pathway
GO:122; negative regulation of transcription by RNA polymerase II
GO:30154; cell differentiation
GO:10628; positive regulation of gene expression
GO:1501; skeletal system development
GO:6816; calcium ion transport
GO:6874; cellular calcium ion homeostasis
GO:7595; lactation
GO:9887; animal organ morphogenesis
And 17 more GO terms Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
GO:785; chromatin
GO:90575; RNA polymerase II transcription regulator complex
GO:43235; receptor complex
Show all GO termsFunction: GO:5515; protein binding
GO:8270; zinc ion binding
GO:46872; metal ion binding
GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:43565; sequence-specific DNA binding
GO:4879; nuclear receptor activity
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:46965; retinoid X receptor binding
GO:70644; vitamin D response element binding
And 4 more GO terms
Homologs of VDR in Model Organisms
In other databases
- LongevityMap
- This gene is present as VDR
External links
- OMIM
- 601769
- Ensembl
- ENSG00000111424
- Entrez Gene
- 7421
- UniGene
- 524368
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- VDR
- GeneCards
- VDR